Study: Non-genetic factors play role in non-diabetic kidney disease among African-Americans
The high rate of non-diabetic kidney disease in African-Americans is strongly associated with variations in a particular gene. Yet, not everyone who inherits these variations develops the disease.
Researchers at Wake Forest Baptist Medical Center are working to find out why.
In a study published in the October issue of the journal Kidney International, the research team evaluated children and siblings of African-Americans on dialysis to determine why some develop kidney disease and others don't. These relatives of the dialysis patients are more likely to inherit the variance in the apolipoprotein L1 (APOL1) gene than members of the general population.
APOL1 gene mutations are associated with up to 40 percent of kidney disease in African- Americans who are treated with dialysis or receive a kidney transplant. This genetic association, which was discovered in 2010 by a team of researchers including Barry Freedman, M.D. professor of nephrology at Wake Forest Baptist, is one of the strongest ever detected for a common disease and helps explain the higher rates of non-diabetic kidney disease among African- Americans relative to the general population.
In this study, the researchers screened 786 close relatives from 470 African-American families with a member who had non-diabetic kidney failure and underwent dialysis. Of the relatives screened, 23 percent had two copies of the gene variant, 47 percent had one copy and 30 percent had no copies. In the general African-American population, the corresponding figures are 12, 39 and 49 percent, respectively.
After adjusting for familial relationships, the researchers found that kidney function, blood pressure and protein in the urine were not significantly different among those with two copies of the variant as compared to those with one or no copies. Weak APOL1 associations with kidney disease were observed after adjusting for age, gender, family age at dialysis and ancestry.
Freedman, the lead author of the study, said the researchers had expected to find a far greater effect of the gene on mild kidney disease in the relatives who had two copies of the variant.
"If the gene alone isn't the trigger, then what is?" he said. "Modifying factors or 'second hits', such as viral infections or environmental factors, must be present to cause kidney disease. More research needs to be conducted in order to identify them.
"We can't change someone's genetic makeup, but if we can find out what the 'second hits' are then hopefully we can find ways to block them and protect people from kidney disease."
The researchers also concluded that there may be limited value in broadly screening African-Americans for this gene variant to detect those with mild kidney disease. This recommendation may change when modifiable second hits are identified, Freedman said. In addition, there may be value in screening certain individuals, particularly relatives of African-American patients on dialysis who may want to donate a kidney.
Provided by Wake Forest University Baptist Medical Center
- Sickle cell trait is not risk factor for kidney disease Sep 14, 2011 | not rated yet | 0
- African-Americans more likely to donate kidney to family member Oct 18, 2011 | not rated yet | 0
- Better ways to predict kidney disease risk for African Americans Oct 14, 2011 | not rated yet | 0
- Gene variant increases risk of kidney disease in African-Americans Oct 24, 2011 | not rated yet | 0
- Gene linked to worsening kidney disease in African-Americans Nov 21, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
Diseases, Conditions, Syndromes 7 hours ago | not rated yet | 0
There are significant cost and risk factors associated with two procedures commonly used to diagnose or treat gastrointestinal problems, according to research presented at Digestive Disease Week (DDW).
Diseases, Conditions, Syndromes 19 hours ago | not rated yet | 0
Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, Mayo Clinic research shows. The findings were being presented at the Digestive Disease ...
Diseases, Conditions, Syndromes 19 hours ago | not rated yet | 0 |
A new case of the deadly coronavirus has been detected in Saudi Arabia where 15 people have already died after contracting it, the health ministry announced on Saturday on its Internet website.
Diseases, Conditions, Syndromes May 18, 2013 | not rated yet | 0
(HealthDay)—Few randomized clinical trials have been done to assess clinical prediction rules for patients with lower back pain, and the trials that have been done are of low quality and do not provide ...
Diseases, Conditions, Syndromes May 17, 2013 | not rated yet | 0 |
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
7 hours ago | not rated yet | 0 |
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
8 hours ago | 5 / 5 (2) | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
7 hours ago | 5 / 5 (1) | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
8 hours ago | 5 / 5 (3) | 0 |
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
12 hours ago | not rated yet | 0
The devastating effect of Alzheimer's disease on bilingual people has been thrown into focus in Canada, where the sudden loss of a second language can leave sufferers feeling like strangers in their own country.
10 hours ago | not rated yet | 0