The role of beta cell regeneration in type 2 diabetes
The World Health Organization (WHO) has declared type 2 diabetes as the epidemic of the 21st century. A study is focusing on understanding the mechanisms underlying insulin resistance and the role of beta-cell regeneration.
Type 2 diabetes develops through a step-wise process, starting by the inability of the body to use insulin effectively which causes pancreatic beta cells to produce more insulin in an attempt to compensate for this phenomenon. Eventually, the beta cells become exhausted and cannot produce enough insulin to overcome insulin resistance and at this point, this condition can progress to diabetes.
A substantial decrease in the number of beta cells due to extensive cell death or decreased proliferation, and/or an impairment of insulin secretion are considered the most likely mechanisms underlying type 2 diabetes. The European BCELL-T2D is aiming to delineate these mechanisms and study the potential of beta-cell regeneration in therapy.
To achieve this, scientists have characterised a mouse model carrying a mutation in the receptor that binds the fat cell-specific hormone leptin. These animals are prone to obesity and type 2 diabetes.
Results so far indicate that insulin resistance starts at 4–9 weeks of age, progresses to frank diabetes (10–18 weeks of age) and finally to advanced diabetes and its complications (after 19 weeks of age). Assessment of the beta-cell mass at each stage has shown an initial expansion in the insulin compensatory phase that disappears along the evolution of the disease.
As a therapeutic intervention, scientists are looking to overcome the proliferation shortage of beta cells by providing cyclin C, a protein that controls cell cycle entry. Ongoing research will determine if sustained beta-cell proliferation has the potential to prevent diabetes debut.
By studying the type 2 diabetes mouse model, scientists have revealed novel insight into the disease development and pathophysiology. Project findings hold great potential of being translated into new therapies in order to prevent and treat this devastating disease and its complications.
Provided by CORDIS
- Researchers find beta cell stress could trigger the development of type 1 diabetes Mar 22, 2012 | not rated yet | 0
- Insulin signaling is distorted in pancreases of Type 2 diabetics Dec 13, 2011 | not rated yet | 0
- Connexins: Providing protection to cells destroyed in Type 1 diabetes Nov 07, 2011 | not rated yet | 0
- Compounds that trigger beta cell replication identified Feb 25, 2009 | not rated yet | 0
- Researchers discover how insulin-producing cells increase during pregnancy Jun 28, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Learning curve of Electromagnetism?
2 hours ago I'm taking a first year physics course and have been having a little trouble with the basics of newtons laws and forces and whatnot, though nothing...
thin glass in liquid
3 hours ago I have one question about optics because I start interested in it. If an object is placed a distance p from a thin glass lens (index of refraction...
How many joules expended for a push up?
6 hours ago Just wondering if any of you can do the calculation that well approximates the amount of joules expended by a push up.
force to keep the folding doors
6 hours ago Hello, I would like to ask you to calculate the force F, which needed to keep the folding doors in this position. I would like to know what is the...
Confusion regarding direction of kinetic friction on inclined plane.
7 hours ago *please help! * The formula for kinetic friction acting on a sliding body is μkN When the body is sliding with constant velocity down an...
13 hours ago Alright, so in Pathfinder (like Dungeons and Dragons) there's a spell that allows you to lift/move stuff within 25 ft with 5 pounds of force. A...
- More from Physics Forums - Classical Physics
More news stories
(HealthDay)—Moderate aerobic exercise prevents fructose-induced hypertriglyceridemia in healthy males, according to a study published online May 14 in Diabetes.
Diabetes May 17, 2013 | 5 / 5 (1) | 0 |
A DNA variant near a digestive enzyme does not only affect risk of developing diabetes but also affects the response to treatment, an international consortium of researchers including the University of Dundee has found.
Diabetes May 17, 2013 | not rated yet | 0 |
(Medical Xpress)—Development of a sophisticated artificial pancreas holds potential to transform the lives of patients with Type 1 diabetes.
Diabetes May 16, 2013 | 5 / 5 (1) | 0 |
A small University at Buffalo study has found for the first time that in Type 1 diabetics, insulin injections exert a strong anti-inflammatory effect at the cellular and molecular level, while even small amounts of glucose ...
Diabetes May 16, 2013 | not rated yet | 0
(HealthDay)—Home diabetes regimens partially explain the increased risk of having a hypoglycemia event during hospitalization among older African-American men with diabetes, according to a study published ...
Diabetes May 14, 2013 | not rated yet | 0
An increasing number of U.S. children are experiencing gastrointestinal issues that require interventions to resolve, according to research presented at Digestive Disease Week (DDW).
6 hours ago | not rated yet | 0 |
Big names in medicine are set to give an upbeat assessment of the war on AIDS on Tuesday, 30 years after French researchers identified the virus that causes the disease.
14 hours ago | 5 / 5 (1) | 0
For combat veterans suffering from post-traumatic stress disorder, 'fear circuitry' in the brain never rests
Chronic trauma can inflict lasting damage to brain regions associated with fear and anxiety. Previous imaging studies of people with post-traumatic stress disorder, or PTSD, have shown that these brain regions can over-or ...
15 hours ago | 5 / 5 (1) | 0 |
The latest makeover to a massive psychiatric tome honored by some, reviled by others and even called the "Bible" of mental disorders is being released Saturday with a host of new changes.
4 hours ago | not rated yet | 0
A new case of the deadly coronavirus has been detected in Saudi Arabia where 15 people have already died after contracting it, the health ministry announced on Saturday on its Internet website.
4 hours ago | not rated yet | 0
A ground-breaking advance in colonoscopy technology signals the future of colorectal care, according to research presented today at Digestive Disease Week(DDW). Additional research focuses on optimizing the minimal withdrawal ...
6 hours ago | 5 / 5 (1) | 0