Simple test may ease management of esophagitis
A simple new test, in which the patient swallows a string, can monitor treatment of eosinophilic esophagitis as effectively as an invasive, expensive and uncomfortable procedure that risks complications, particularly in children.
Researchers from the University of Illinois at Chicago College of Medicine, working in collaboration with clinician-investigators at the University of Colorado Denver/Children's Hospital Colorado and Lurie Children's Hospital in Chicago, reported their findings in a study published recently online in the journal Gut.
Eosinophilic esophagitis, or EoE, is a food-allergy inflammatory disease of the esophagus in both children and adults. While rare, it is steadily increasing in incidence. In EoE, inflammatory cells in the body called eosinophils attack the esophagus. The esophagus narrows until food cannot pass, causing painful impactions.
"Most cases are first encountered in the emergency room, where a child is brought in because something he ate is caught in his esophagus," says Steven Ackerman, UIC professor of biochemistry and molecular genetics and co-principal investigator on the study.
Eosinophils produce specific proteins. Because these inflammatory cells are not normally found in the esophagus, these proteins serve as biomarkers and can indicate the extent of inflammation in the esophagus.
Currently, physicians diagnose EoE and monitor its treatment by endoscopy. A lighted, flexible instrument is inserted down the esophagus and used to obtain six to eight tissue samples for biopsy from sections along its length from throat to stomach.
A child may require 10, 15, or even 20 such procedures over three or four years, say two of the report's authors, co-principal investigator Dr. Glenn Furuta, professor of pediatrics at the University of Colorado at Denver, and Dr. Amir Kagalwalla, associate professor of pediatrics at Northwestern University.
The new method, the Esophageal String Test, or EST, uses a capsule containing a yard-long string. One end of the string is taped to the patient's cheek before the capsule is swallowed, and the string spools out of the dissolving capsule, stretching through the esophagus, the stomach and the small intestine. The string becomes coated with digestive tract secretions and can be removed for analysis.
Ackerman and Furuta tested samples from the string in the esophagus region looking for eosinophil proteins to show evidence of inflammation. Levels detected by the string test and by biopsy were both shown to indicate disease accurately.
The researchers recruited 41 patients ages 7-20, who were to undergo endoscopy and biopsy. Participants swallowed the capsule the night before endoscopy, and the string was removed just prior to that procedure. The researchers believe the string may not need to remain in place for so long, and the test could be performed in a single visit to the doctor's office.
Although the string test may never completely replace endoscopy-with-biopsy, particularly for diagnosis, the authors conclude, "it certainly has the potential to significantly improve the evaluation and treatment of patients who require repeated assessments."
Journal reference: Gut
Provided by University of Illinois at Chicago
- String probes for devastating childhood digestive disease Jul 30, 2008 | not rated yet | 0
- Mast cell tryptase test may aid in diagnosis of eosinophilic esophagitis May 04, 2010 | not rated yet | 0
- Genetic marker for painful food allergy points to improved diagnosis, treatment Mar 09, 2012 | not rated yet | 0
- Food elimination diet identifies causes of difficulty swallowing and swelling of the throat Jun 20, 2012 | not rated yet | 0
- Biopsies may overlook esophagus disease—Study reveals limitations in detecting allergic disorder Sep 06, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
gravity is std. therefore can we rate a 'mass at height' by watts?
1 hour ago For example.... wind turbines are primarily listed by their wattage (1.5MW etc.) Presumably their output is varied according to rotational speed, so...
Calculating on-axis elements of a solenoid
13 hours ago I wanted to mention that this solenoid has many winds over many layers. The thickness of the windings is 2.4 inches coming off of the engineering...
latitude & longitude & air pressure
14 hours ago Hi there, I have a peculiar question. Imagine that you are in a earth position, obtained by google, that gives you the latitude and longitude....
Differences of Classical Mechanics when learned with Calc vs algebra?
17 hours ago what are the differences? Every example I find usually has a derivative or integral or some kind of calculus defined concept that seems to make it...
what is the distance traveled
21 hours ago A rough sketch of experiment. Image: http://i43.tinypic.com/14t4sk5.png the red dots represent a side view of path traveled, F is downward force...
Image of a Convex Lens Cut in Half Horizontally
May 22, 2013 Hello everyone, A friend of mine came up with this question in class and I really do not have a good answer. Suppose you have a convex lens...
- More from Physics Forums - Classical Physics
More news stories
The negative effects of poorly controlled asthma symptoms on sleep quality and academic performance in urban schoolchildren has been confirmed in a new study.
Inflammatory disorders May 21, 2013 | not rated yet | 0
Patients with inflammatory bowel disease (IBD) are at higher risk of melanoma, a form of skin cancer, report researchers at Mayo Clinic. Researchers found that IBD is associated with a 37 percent greater risk for the disease. ...
Inflammatory disorders May 20, 2013 | 4.5 / 5 (2) | 0
(Medical Xpress)—Inflammation is an important response in the body - it helps you to kill off invaders such bacteria that could cause a harmful infection. But if it's chronic or uncontrolled, inflammation can also cause ...
Inflammatory disorders May 14, 2013 | 5 / 5 (1) | 0 |
New research by medical students working in the Breathe Well Centre of Research Excellence at the UTAS School of Medicine has revealed swimming has health benefits for young people with asthma, with no adverse effects on ...
Inflammatory disorders May 10, 2013 | 5 / 5 (1) | 0
An estimated 4,837,000 asthmatics with allergic bronchopulmonary aspergillosis (ABPA) could benefit substantially from antifungal treatment, say researchers from The University of Manchester and the University of Toronto.
Inflammatory disorders May 08, 2013 | not rated yet | 0
(Medical Xpress)—Research by U of T Mississauga psychology professor Glenn Schellenberg reveals that two key personality traits – openness-to-experience and conscientiousness—predict better than IQ ...
1 hour ago | not rated yet | 0 |
Professor Michael Jennings, Deputy Director of the Institute for Glycomics at Griffith University, was part of an international team that discovered the previously unknown pathway of how the bacterium colonizes people.
38 minutes ago | 5 / 5 (1) | 0 |
Scientists at Newcastle University have shed new light on how the brain tunes in to relevant information.
34 minutes ago | 5 / 5 (1) | 0 |
New techniques in imaging of brain activity developed by Jean Gotman, from McGill University's Montreal Neurological Institute, and his colleagues lead to improved treatment of patients suffering from epilepsy. The combination ...
35 minutes ago | not rated yet | 0
Studying the networks of connections in the brains of people affected by schizophrenia, bipolar disease or depression has allowed Dr. Peter Williamson, from Western University, to gain a better understanding of the biological ...
34 minutes ago | not rated yet | 0
(Medical Xpress)—Scientists from the Joint Center for Structural Genomics (JCSG) at SLAC National Accelerator Laboratory have determined the 3-D structure of the chemically active part of an enzyme involved ...
1 hour ago | not rated yet | 0 |