New test may uncover deadly hypertension disease in pregnancy
This shows from left: Dr. Alex Soffici, Professor Patrick Daugherty, and graduate researcher Serra Elliott. Credit: University of California - Santa Barbara
Collaborators at Cottage Health System and University of California, Santa Barbara (UCSB) have identified biomarkers that may yield a revolutionary diagnostic test for pre-eclampsia, a complex and potentially life-threatening hypertensive condition affecting 5% of pregnancies worldwide.
The most common dangerous complication of pregnancy, pre-eclampsia is potentially fatal and often mimics or is confused with other pregnancy-related conditions—such as swelling, gastric pain, and high blood pressure. Pre-eclampsia can lead to eclampsia, which carries a maternal mortality rate of 1.8 percent worldwide.
Through a partnership funded by the Santa Barbara Cottage Hospital Research Grant Program, the study was led by Dr. Alex Soffici, perinatologist with Santa Barbara Cottage Hospital, and Dr. Patrick Daugherty, professor of chemical engineering at UCSB. Plasma samples were collected over a period of two years from both normal-outcome and pre-eclampsia pregnancy patients at Santa Barbara Cottage Hospital, and then analyzed by UCSB graduate researcher Serra Elliott to identify candidate biomarkers.
"We are seeing the early stages of something that could be quite big," said Soffici. "Therapeutics for pre-eclampsia are on the horizon."
The group discovered that certain antibodies are present in the blood of patients with pre-eclampsia, but not in women with healthy pregnancies. Their results suggest that this new diagnostic test could effectively distinguish pre-eclampsia syndrome from conditions with similar symptoms. The collaborators' research continues in an ongoing study that could lead to technology available to clinical settings.
"We developed a separation process to sift through enormous numbers of distinct molecules present in blood to identify those few that are uniquely present in patients with pre-eclampsia," explained Daugherty. "Since our process simultaneously identifies biochemical reagents that can capture the disease biomarkers, there is an opportunity to create an effective diagnostic test for this prevalent disorder and possibly for other diseases where definitive tests are not yet available."
Elliott, lead scientist on the project, recently presented their findings at a conference for the International Society of the Study of Hypertension in Pregnancy in Geneva, Switzerland. "There are very few groups in the world working on this technology and we have found it to be exactly what the international research community was looking for. This project has great promise," commented Soffici.
Soffici added, "We are grateful to the Cottage Health System administration and to UCSB leaders for recognizing the great value in cooperation between clinicians and researchers, and for breaking down many of the barriers that previously existed for this kind of project."
Provided by University of California - Santa Barbara
- Stroke risk in pregnant women 2.4 times higher Jul 08, 2011 | not rated yet | 0
- New study suggests dietary supplement can protect against pre-eclampsia May 20, 2011 | not rated yet | 0
- Miscarriage and infertility treatment increase pre-eclampsia risk Dec 18, 2008 | not rated yet | 0
- Pre-eclampsia linked to thyroid problems Nov 18, 2009 | not rated yet | 0
- Test for pre-eclampsia developed May 04, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
There are significant cost and risk factors associated with two procedures commonly used to diagnose or treat gastrointestinal problems, according to research presented at Digestive Disease Week (DDW).
Diseases, Conditions, Syndromes 11 hours ago | not rated yet | 0
Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, Mayo Clinic research shows. The findings were being presented at the Digestive Disease ...
Diseases, Conditions, Syndromes 11 hours ago | not rated yet | 0 |
A new case of the deadly coronavirus has been detected in Saudi Arabia where 15 people have already died after contracting it, the health ministry announced on Saturday on its Internet website.
Diseases, Conditions, Syndromes May 18, 2013 | not rated yet | 0
(HealthDay)—Few randomized clinical trials have been done to assess clinical prediction rules for patients with lower back pain, and the trials that have been done are of low quality and do not provide ...
Diseases, Conditions, Syndromes May 17, 2013 | not rated yet | 0 |
A new, highly sensitive blood test that quickly detects even the lowest levels of malaria parasites in the body could make a dramatic difference in efforts to tackle the disease in the UK and across the world, according to ...
Diseases, Conditions, Syndromes May 17, 2013 | not rated yet | 0
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
14 minutes ago | not rated yet | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
14 minutes ago | not rated yet | 0 |
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
4 hours ago | not rated yet | 0
The devastating effect of Alzheimer's disease on bilingual people has been thrown into focus in Canada, where the sudden loss of a second language can leave sufferers feeling like strangers in their own country.
2 hours ago | not rated yet | 0
Patients with treatment-resistant major depression saw dramatic improvement in their illness after treatment with ketamine, an anesthetic, according to the largest ketamine clinical trial to-date led by researchers from the ...
11 hours ago | 4.7 / 5 (3) | 0 |
Research presented at Digestive Disease Week (DDW) explores new methods for managing digestive health through diet and lifestyle.
11 hours ago | not rated yet | 1