Low levels of vitamin D are associated with mortality in older adults

October 2, 2012

Low levels of vitamin D and high levels of parathyroid hormone are associated with increased mortality in African American and Caucasian older adults, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM). The study also indicates that the potential impact of remediating low vitamin D levels is greater in African Americans than Caucasians because vitamin D insufficiency is more common in African Americans.

For the past several years, there has been considerable interest in the role vitamin D plays in improving health and preventing disease. Low levels of vitamin D have been directly associated with various forms of cancer and cardiovascular disease. Most studies regarding the health effects of low vitamin D levels have been conducted on persons of European origin, but the current study examines the relationship between vitamin D and mortality in blacks and whites.

"We observed vitamin D insufficiency (defined as blood levels <20 ng/ml), in one third of our study participants. This was associated with nearly a 50 percent increase in the mortality rate in older adults," said Stephen B. Kritchevsky, PhD, Professor of Internal Medicine and Transitional Science at the Wake Forest School of Medicine, and lead researcher of this study. "Our findings suggest that low levels of vitamin D may be a substantial public health concern for our nation's ."

In this study, 2,638 and African-Americans aged 70-79 years were asked to fast for 12-hours, after which a blood sample was collected to determine levels of vitamin D. Every six months were contacted to ascertain their medical condition. This study determined the proportion of deaths among participants of with different vitamin D levels. In addition to many , the time of year was also taken into account due to the seasonal effects on vitamin D. Researchers found that levels of vitamin D less than 30 ng/ml were associated with significantly increased all-cause mortality.

"We all know that is important to overall health and our study adds to a growing body of literature that underscores the importance of vitamin D and indicates that poor vitamin D nutrition is wide-spread," said Kritchevsky. "The good news is it's easy to improve vitamin D status either through increased skin exposure to sunlight or through diet or supplements."

Explore further: Low vitamin D levels may contribute to development of Type 2 diabetes

More information: The study, "25-Hydroxyvitamin D, Parathyroid Hormone, and Mortality in Black and White Older Adults: The Health ABC Study," appears in the November 2012 edition of JCEM.

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1 / 5 (1) Oct 02, 2012
50% increased mortality rate. So now it's 150%?

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