Open access initiative reveals drug hits for deadly neglected tropical diseases

The Drugs for Neglected Diseases initiative (DNDi) and Medicines for Malaria Venture (MMV) announce today the identification of three chemical series targeting the treatment of deadly neglected tropical diseases (NTDs), through DNDi's screening of MMV's open access Malaria Box. The resulting DNDi screening data are among the first data generated on the Malaria Box to be released into the public domain, exemplifying the potential of openly sharing drug development data for neglected patients.

The open access Malaria Box is an MMV initiative launched in December 2011 to catalyse drug discovery for malaria and neglected diseases. It contains 400 molecules, selected by experienced medicinal chemists to offer the broadest possible and is available free of charge. In return, MMV requests that any data gleaned from research on the Malaria Box are shared in the public domain within two years. To date, more than 100 Malaria Boxes have been delivered to over 20 countries for research on diseases including malaria, neglected diseases, HIV and cancer.

DNDi, in partnership with the Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, screened all the compounds in the Malaria Box against the parasites responsible for the three NTDs on which DNDi mainly focuses: (), leishmaniasis (including , or kala azar, also known as black fever), and Chagas disease. This initial screen identified two potential drug series for the treatment of sleeping sickness and one for leishmaniasis. The DNDi screens have yielded valuable information that will strengthen DNDi's research pipeline. All the from DNDi's screen, together with the existing preliminary data from MMV, are now publicly available on the open-source ChEMBL database.

"This is a really great example of partnership in action," said Dr David Reddy, MMV's CEO. "MMV and DNDi already work synergistically to tackle tropical diseases. Now, through the Malaria Box we can freely explore molecules that could potentially work against several debilitating tropical diseases, for the benefit of vulnerable populations the world over. It's hugely gratifying to see the idea of the Malaria Box starting to pay off."

Today, DNDi and MMV also announce an agreement to collaborate on research by sharing compounds from their respective preclinical pipelines. Compounds provided by DNDi will be screened by MMV for antimalarial activity, and early stage compounds provided by MMV will be assessed by DNDi for their activity against the parasites causing sleeping sickness, leishmaniasis, Chagas disease, and filarial parasitic-worm diseases. This agreement highlights the potential for increased collaboration among Product Development Partnerships (PDPs) like MMV and DNDi to accelerate the development of treatments for some of the world's most neglected diseases and patients.

" initiatives, such as the Malaria Box, are part of an encouraging new paradigm," says Dr Bernard Pécoul, Executive Director of DNDi. "We have to maintain a sharp focus on neglected patient needs and increase our efforts to open up research knowledge, reduce duplication in research efforts, and work together to fill the R&D gaps for diseases that afflict the poorest populations of the world."

Provided by Drugs for Neglected Diseases Initiative

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Old drug shows new promise to treat leishmaniasis

Feb 02, 2012

(Medical Xpress) -- A study published yesterday shows that a drug called fexinidazole could potentially be used to treat visceral leishmaniasis, a parasitic disease that kills 50 000 to 60 000 people ...

Recommended for you

UN chief: Ebola cases in Mali a 'deep concern'

8 hours ago

The United Nations chief warned Friday that Ebola may be easing in part of West Africa but is still hitting hard in other areas and outpacing the international response.

Ebola death toll rises to 5,459: WHO

14 hours ago

The World Health Organization said Friday that 5,459 people had so far died of Ebola out of a total 15,351 cases of infection in eight countries since late December 2013.

Flu season off to a slow start ... for now

17 hours ago

(HealthDay)—This year's flu season is off to a slow but detectable start. And it appears to be a typical one that's likely to peak in January or February, a leading U.S. health official says.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.