ACOG OKs cell free DNA prenatal testing for high-risk women

ACOG OKs cell free DNA prenatal testing for high-risk women
Cell free fetal DNA testing is an effective screening tool for fetal aneuploidy and should be offered to high-risk women, but should not form part of routine prenatal laboratory assessment, according to a Committee Opinion published in the December issue of Obstetrics & Gynecology.

(HealthDay)—Cell free fetal DNA testing is an effective screening tool for fetal aneuploidy and should be offered to high-risk women, but should not form part of routine prenatal laboratory assessment, according to a Committee Opinion published in the December issue of Obstetrics & Gynecology.

The American College of Obstetricians and Gynecologists' Committee on Genetics and the Society for Maternal-Fetal Medicine Publications Committee reviewed emerging clinical and scientific data on the use of noninvasive prenatal testing using cell free fetal DNA from the plasma of pregnant women.

The authors recommend that cell free fetal should only be offered to patients at increased risk of aneuploidy. Testing can identify about 98 percent of Down syndrome cases with a less than 0.5 percent false-positive rate. Testing has not been sufficiently evaluated in low-risk women or those with multiple gestations and consequently should not be offered to these groups. Pretest counseling should be used to inform patients of their choices and should emphasize that a negative test does not ensure an unaffected pregnancy. Testing can only screen for common trisomies and does not provide other genetic information about the pregnancy. Patients with a positive result should be referred for genetic counseling and offered invasive testing to confirm the results.

"Although no prospective trials of this technology are available, cell free fetal DNA appears to be the most effective screening for aneuploidy in high-risk ," the authors write.

More information: Full Text

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Cesarean section rates in Portugal decline by 10 percent

Mar 02, 2015

A new study reports a significant decline in the rate of cesarean section (C-section) births in Portugal. Findings published in Acta Obstetricia et Gynecologica Scandinavica, a journal of the Nordic Federation of Societies of Obs ...

Bariatric surgery affects risk of pregnancy complications

Feb 25, 2015

Bariatric surgery has both a positive and negative influence on the risk of complications during subsequent pregnancy and delivery, concludes a new study from Karolinska Institutet in Sweden. The results, which are published ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.