Single C-peptide as good as full mixed-meal tolerance test

Single C-peptide as good as full mixed-meal tolerance test
For children and adolescents with type 1 diabetes, the 90-minute mixed-meal tolerance test (MMTT)-stimulated C-peptide is a highly sensitive and specific measure of area under the curve and peak C-peptide and may be used as an alternative to a full MMTT, according to a study published online Oct. 30 in Diabetes Care.

(HealthDay)—For children and adolescents with type 1 diabetes, the 90-minute mixed-meal tolerance test (MMTT)-stimulated C-peptide (CP; 90CP) is a highly sensitive and specific measure of area under the curve (AUC) and peak CP and may be used as an alternative to a full MMTT, according to a study published online Oct. 30 in Diabetes Care.

Rachel E.J. Besser, Ph.D., from Peninsula Medical School at the University of Exeter in the United Kingdom, and colleagues examined whether 90CP or fasting CP (FCP) can be used as alternatives to a full MMTT. In 421 patients younger than 18 years with type 1 , CP was measured during 1,334 MMTTs at three, nine, 18, 48, and 72 months of diabetes duration.

The researchers found a correlation for AUC CP of 0.96 for 90CP and 0.84 for FCP. AUC CP ≥23 nmol/L/150 min was the equivalent cut-off for peak CP ≥0.2 nmol/L, with 98 percent sensitivity and 97 percent specificity. A 90CP ≥0.2 nmol/L correctly classified 96 percent of patients using AUC or peak CP, while an FCP ≥0.1 nmol/L correctly classified 83 and 85 percent of patients, respectively. Only a small difference was noted between peak and 90CP. Patients with longer duration of diabetes and younger age had an earlier occurring CP peak.

"In conclusion, our study demonstrates that, in children and with , a mixed-meal stimulated 90-min CP is a highly sensitive, specific, and practical alternative measure to peak and AUC CP, with advantages over FCP," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Chronic periodontitis increases risk of psoriasis

Jul 19, 2012

(HealthDay) -- Patients with chronic periodontitis (CP) are 1.5 times more likely to be diagnosed with psoriasis, and this risk is lessened but not nullified by CP treatment using gingivectomy or periodontal ...

Recommended for you

Economic burden of prediabetes up 74 percent over five years

Nov 20, 2014

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

Gynoid fat resists metabolic risks of obesity

Nov 19, 2014

(HealthDay)—The differences in the developmental profiles of upper-body and lower-body fat depots may explain their opposing associations with obesity-related metabolic disease, according to research published ...

Treating diabetes one meal at a time

Nov 19, 2014

Recent estimates project that as many as one in three American adults will have diabetes in 2050. The American Diabetes Association observes November as American Diabetes Month, and this year's theme is America ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.