Increased risk of carotid artery wall thickening in COPD

November 12, 2012
Increased risk of carotid artery wall thickening in COPD
For older adults with chronic obstructive pulmonary disease, the likelihood of carotid artery thickening is increased and vulnerable lipid core plaques are more frequent than in controls with normal lung function, according to a study published online Nov. 9 in the American Journal of Respiratory and Critical Care Medicine.

(HealthDay)—For older adults with chronic obstructive pulmonary disease (COPD), the likelihood of carotid artery thickening is increased and vulnerable lipid core plaques are more frequent than in controls with normal lung function, according to a study published online Nov. 9 in the American Journal of Respiratory and Critical Care Medicine.

Lies Lahousse, Ph.D., M.P.H., from Ghent University in Belgium, and colleagues investigated the prevalence of carotid wall thickening, the different components of carotid artery plaque, and their associations with severity of airflow limitation in a cross-sectional study involving 253 patients with COPD and 920 controls from the Rotterdam Study (age 55 years and older).

The researchers found that, compared with controls with normal lung function, COPD cases had a significantly increased risk of presentation with carotid artery wall thickening on ultrasonography (odds ratio, 2.0). This risk increased significantly with airflow limitation severity. On , in COPD cases, vulnerable lipid core plaques were significantly more frequent than in controls (odds ratio, 2.1).

"In conclusion, this study shows an increased risk of carotid artery plaque formation and of presence of vulnerable plaques with a lipid core in population-based elderly patients with COPD," the authors write. "Clinicians should be aware that asymptomatic carotid atherosclerosis is more prevalent in subjects with COPD and that COPD as a systemic inflammatory disease might lead to vulnerable plaques by inducing or aggravating the presence of a lipid core."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study confirms link between rheumatoid arthritis and COPD

May 26, 2011

Patients with rheumatoid arthritis are two times more likely to have concurrent chronic obstructive pulmonary disease (COPD) than healthy controls -- an association which was sustained even when variables such as age, gender, ...

Pulmonary artery enlargement predicts exacerbation in COPD

September 4, 2012

(HealthDay)—For patients with chronic obstructive pulmonary disease (COPD), computed tomographic (CT) measurement of pulmonary artery enlargement, as determined by a ratio of the diameter of the pulmonary artery to the ...

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.