Cooling cardiac arrest patients to lower body temps improved survival

Cooling patients resuscitated after sudden cardiac arrest to lower body temperatures may be associated with increased survival and better functional ability, according to late-breaking clinical trial research presented at the American Heart Association's Scientific Sessions 2012.

The full manuscript for Pilot Trial of Two Levels of Hypothermia in Comatose Survivors from Out-of-Hospital , is published in Circulation, a journal of the .

In the study of 36 people in Madrid, Spain, researchers found that 44 percent of patients who underwent therapeutic cooling to 32C (89.6F) after cardiac arrest survived without severe six months after treatment. That compared to 11 percent of those cooled to 34C (93.2F).

Researchers defined dysfunction as the inability to perform the normal tasks of everyday living, including bathing, dressing and walking.

Each year in the United States, about 382,800 people suffer cardiac arrest outside of a hospital, according to the American Heart Association. The life-threatening condition occurs when the heart suddenly stops functioning. Immediate CPR and emergency medical care must be provided within minutes to restore a regular rhythm - or the person will not survive.

Once a normal heartbeat is restored, treatment for comatose patients includes therapeutic cooling to decrease the body's oxygen requirements, which can help prevent associated with the cardiac arrest. American Heart Association and International Liaison Committee on Resuscitation (ILCOR) recommendations are to cool body temperature to 32C-34C, but the optimal temperature within this range is unclear.

"Although the results suggest a better outcome with lower levels of target temperature, they should be interpreted with caution," said Esteban Lopez-de-Sa, M.D., lead researcher and head of the Cardiac Critical Care Unit and at La Paz University Hospital in Madrid, Spain. "They may be due to multiple factors other than the effect of lower target temperature."

The benefits were observed in patients whose initial detected rhythm was shockable, he said.

Thirty-six patients with out-of-hospital cardiac arrest participated in the single-center trial, from March 2008-August 2011. Their average age was 64, 89 percent were male, and all were white.

Researchers randomly assigned patients to receive therapeutic cooling to either 32C or 34C for 24 hours, followed by gradual rewarming for 12-24 hours. Patients were cooled internally with intravenous cold saline followed by an internal catheter and temperature management system inserted directly into the main vein from the lower body to the heart.

"Since extremely low temperatures below 30C are associated with complications, it's critical to know the optimal level of cooling" Lopez-de-Sa; said. "The aim of the study was to provide initial information for future research about whether controlling hypothermia levels can improve outcome."

More information: newsroom.heart.org/pr/aha/document/DISCLOSURES.pdf

Related Stories

Post-cardiac arrest care key to survival

date Oct 23, 2008

The urgent need for treatment doesn't end when a person regains a pulse after suffering sudden cardiac arrest — healthcare providers need to move quickly into post-cardiac arrest care to keep a person alive and ensure the ...

Recommended for you

1950s drug is future heart treatment

date 17 hours ago

Oxford University researchers have found a promising future treatment for heart disease, going back to a drug first developed in 1950.

Time is muscle in acute heart failure

date May 21, 2015

Urgent diagnosis and treatment in acute heart failure has been emphasised for the first time in joint recommendations published today in European Heart Journal.

Common mutation linked to heart disease

date May 20, 2015

A common mutation in a gene that regulates cholesterol levels may raise the risk of heart disease in carriers, according to a new UConn Health study.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.