Novel device benefits type 3 osteogenesis imperfecta

Novel device benefits type 3 osteogenesis imperfecta
In children with type 3 osteogenesis imperfecta and thoracic insufficiency syndrome, thoracic elongation surgery using a novel expandable spino-thoracic fixation device significantly improves pulmonary function, weight gain, and spinal deformities, without significant complications, according to a study published online Nov. 7 in Spine.

(HealthDay)—In children with type 3 osteogenesis imperfecta (OI) and thoracic insufficiency syndrome (TIS), thoracic elongation surgery using a novel expandable spino-thoracic fixation device significantly improves pulmonary function, weight gain, and spinal deformities, without significant complications, according to a study published online Nov. 7 in Spine.

Leon Kaplan, M.D., of the Hadassah Hebrew University Medical Center in Jerusalem, and colleagues conducted a prospective series study to examine outcomes of four children aged 8 to 12 years with type 3 OI and TIS who underwent surgery with a novel expandable spino-thoracic fixation device.

After an average follow-up of 24 months, the researchers found that the mean Cobb angle in the coronal plane was improved up to 32 percent. Pulmonary function improved for all , with clinically significant increases in forced vital capacity, forced expiratory flow, and partial pressure of oxygen values, and normalization of partial pressure of carbon dioxide values. Patient weight increased, with patients moving from below the third percentile to the third to seventh percentile at the six-month follow-up. All patients and their caregivers reported improved self-image and functional level.

"Thoracic elongation improved , facilitated weight gain, and made an indirect correction of spinal deformities (Cobb angle) by over 30 percent, with no significant complications," the authors write. "Due to the rarity of this condition, a multicenter study to gain experience in a larger number of patients is recommended."

One or more of the authors disclosed receipt of benefits from a commercial entity related directly or indirectly to this study.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Scoliosis surgery improves adolescents' quality of life

Nov 02, 2012

(HealthDay)—Surgical treatment of adolescent idiopathic scoliosis (AIS) significantly improves quality of life (QOL), according to research published online Oct. 22 in the Journal of Spinal Disorders & ...

In RA, hand surgery improves function, appearance

Sep 03, 2012

(HealthDay)—Treating rheumatoid arthritis (RA) patients with severe hand deformities with a silicone metacarpophalangeal joint arthroplasty (SMPA) procedure produces significant, long-term improvement in hand function and ...

Lasting efficacy for minimally-invasive spinal fusion

Oct 03, 2012

(HealthDay)—For patients undergoing spinal fusion by minimally-invasive lateral lumbar interbody fusion (LLIF), the procedure is safe and effective based on a follow-up of at least two years, according ...

Recommended for you

Ebola death toll passes 7,500

11 hours ago

More than 7,500 people have now died from the Ebola virus, as the number of cases climbs towards 20,000, the World Health Organization said Monday.

Ebola-infected Italian doctor 'recovering'

11 hours ago

An Italian doctor who contracted Ebola in west Africa is recovering but is still in an isolation unit, the specialist clinic in Rome treating him said Monday.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.