Gauging the accuracy of breast cancer biomarker tests

November 1, 2012

A team led by David Rimm, professor of pathology at Yale School of Medicine, investigated protein expression in breast tissue biomarkers to determine whether the time from tissue removal to fixation in preservative can affect the accuracy of testing for cancer.

The study appears in the Journal of the .

An inaccurate measurement can result in false-negative results.

The researchers found significant changes in several of the proteins, and recommend that more testing be done to ensure accurate assessment of tissue biomarkers for the presence of cancer.

Explore further: False negative tests in breast cancer may lead to wrong drug choice

More information: Read the study: jnci.oxfordjournals.org/content/early/2012/10/18/jnci.djs438.full

Related Stories

Addressing high false-positive rates for mammograms

June 13, 2011

We've heard it repeatedly: early detection is key to surviving breast cancer. But even with recent advances in mammography, finding indications of breast cancer before it can metastasize remains a problem. Scientists at Pacific ...

Singling out the real breast cancer among the lumps

October 25, 2011

(Medical Xpress) -- Early detection of breast cancer saves thousands of lives each year. But screening for breast cancer also produces false alarms, which can cause undue stress and costly medical bills. Now, a recent study ...

Recommended for you

Study: Enhancing cancer response to radiation

December 2, 2016

OHSU researcher Sudarshan Anand, Ph.D., has a contemporary analogy to describe microRNA: "I sometimes compare MicroRNA to tweets—they're short, transient and constantly changing."

Rare childhood disease linked to major cancer gene

December 1, 2016

A team of researchers led by a University of Rhode Island scientist has discovered an important molecular link between a rare childhood genetic disease, Fanconi anemia, and a major cancer gene called PTEN. The discovery improves ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.