Higher pulse wave velocity seen in well-controlled diabetes

November 10, 2012
Higher pulse wave velocity seen in well-controlled diabetes
Pulse wave velocity is higher among patients with well-controlled type 2 diabetes when compared to controls, and is associated with white matter lesions, according to a study published online Nov. 5 in Diabetes Care.

(HealthDay)—Pulse wave velocity is higher among patients with well-controlled type 2 diabetes when compared to controls, and is associated with white matter lesions, according to a study published online Nov. 5 in Diabetes Care.

Esben Laugesen, M.D., from Aarhus University Hospital in Noerrebrogade, Denmark, and colleagues measured arterial stiffness with carotid-femoral pulse wave velocity and cerebral white matter lesions by (qualitatively graded by the Breteler scale) in 89 patients diagnosed with type 2 diabetes in the past five years and 89 matched controls. The authors note that arterial stiffness is associated with cardiovascular events and white matter lesions are associated with stroke.

The researchers found that the diabetes group had excellent glycemic control and had and lower total cholesterol than controls. However, even after adjusting for confounding variables, including age, sex, diabetes, , 24-hour mean arterial blood pressure, and medications, they had significantly higher carotid-femoral pulse wave velocity, which was significantly associated with Breteler score and cerebral white matter lesion volume.

"Pulse wave velocity was higher among patients with well-controlled type 2 diabetes compared with controls and was independently associated with white matter lesions," Laugesen and colleagues conclude. "Pulsed wave velocity may represent a clinically relevant parameter in the evaluation of cerebrovascular disease risk in type 2 diabetes."

The study was partially funded by research grants from the Foundation.

Explore further: A novel method for simultaneously measuring blood pressure and arterial stiffness

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Metabolic syndrome linked to arterial stiffness in CKD

June 4, 2012

(HealthDay) -- For patients with chronic kidney disease (CKD), those with metabolic syndrome (MetS) have increased arterial stiffness but no increase in endothelial dysfunction, compared to those without MetS, according to ...

Subclinical atherosclerosis noted in diffuse scleroderma

August 29, 2012

(HealthDay)—Patients with diffuse systemic sclerosis (SSc), without any clinical evidence of cardiovascular disease, have indicators of subclinical atherosclerosis, according to a study published online Aug. 16 in Arthritis ...

White matter structural changes ID'd in children with T1DM

September 17, 2012

(HealthDay)—Children with type 1 diabetes have significant structural differences in the white matter of their brain compared to healthy children, which correlates with hemoglobin A1c (HbA1c) values, according to a study ...

Recommended for you

Do germs cause type 1 diabetes?

May 16, 2016

Germs could play a role in the development of type 1 diabetes by triggering the body's immune system to destroy the cells that produce insulin, new research suggests.

Melatonin signaling is a risk factor for type 2 diabetes

May 12, 2016

A sleeping pancreas releases less insulin, but how much insulin drops each night may differ from person to person, suggests a study published May 12, 2016 in Cell Metabolism. Up to 30 percent of the population may be predisposed ...

New gene for familial high cholesterol

May 12, 2016

New research from Denmark reveals the gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol. Familial hypercholesterolemia is the most common genetic disorder leading to premature ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.