Home field advantage: Intravaginal immunization may help protect against infection

November 12, 2012

Sexually-transmitted diseases (STDs) enter the body through the mucosal epithelial cells and the ability to direct pathogen-clearing T-cells to points of infection may be the critical element in developing successful vaccines against these infections.

In a study published in the Journal of Clinical Investigation, researchers led by John Schiller at the investigated the immune response to intravaginal immunization in mice infected with a form of the HPV virus carrying a model antigen.

They found that intravaginal immunization significantly increased the number of immune cells present in the vaginal mucosa compared with a general immune system booster.

These results indicate that site-specific vaccination enhances the local and may be useful in developing STD vaccines.

Explore further: Skin sentry cells promote distinct immune responses

More information: Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cells, Journal of Clinical Investigation, 2012.

Related Stories

Skin sentry cells promote distinct immune responses

July 21, 2011

A new study reveals that just as different soldiers in the field have different jobs, subsets of a type of immune cell that polices the barriers of the body can promote unique and opposite immune responses against the same ...

Recommended for you

Epigenomic changes are key to innate immunological memory

August 31, 2015

A research team led by Keisuke Yoshida and Shunsuke Ishii of the RIKEN Molecular Genetics Laboratory has revealed that epigenomic changes induced by pathogen infections, mediated by a transcription factor called ATF7, are ...

Team finds early inflammatory response paralyzes T cells

August 18, 2015

In a discovery that is likely to rewrite immunology text books, researchers at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can "paralyze" CD4 T cells, immune components that help ...

SIV shrugs off antibodies in vaccinated monkeys

August 11, 2015

New research on monkeys vaccinated against HIV's relative SIV calls into question an idea that has driven AIDS vaccine work for years. The assumption: a protective vaccine only needs to stimulate moderate levels of antibodies ...

2 comments

Adjust slider to filter visible comments by rank

Display comments: newest first

saraet
not rated yet Nov 13, 2012


DateHSV...com is a place for you to find information, friendship, hope, support, and romance. HPV information herpes dating herpes personals HSV HIV/AIDS STD medical treatments and information. No matter what kind of STDs you have, or just curious to see what's on here can register profile and conduct profile search for free.
saraet
not rated yet Nov 13, 2012
DateHSV...com is a place for you to find information, friendship, hope, support, and romance. HPV information herpes dating herpes personals HSV HIV/AIDS STD medical treatments and information. No matter what kind of STDs you have, or just curious to see what's on here can register profile and conduct profile search for free.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.