Major illness increases venous thrombosis risk

Major illness increases venous thrombosis risk
People with major illnesses, including liver or kidney disease, rheumatoid arthritis, multiple sclerosis, heart failure, hemorrhagic stroke, or arterial thrombosis, have an increased risk of venous thrombosis that dramatically increases during periods of immobilization or in the presence of thrombophilia, according to research published online Oct. 26 in the Journal of Thrombosis and Haemostasis.

(HealthDay)—People with major illnesses, including liver or kidney disease, rheumatoid arthritis, multiple sclerosis, heart failure, hemorrhagic stroke, or arterial thrombosis, have an increased risk of venous thrombosis that dramatically increases during periods of immobilization or in the presence of thrombophilia, according to research published online Oct. 26 in the Journal of Thrombosis and Haemostasis.

In an effort to evaluate the effect of several major illnesses on the development of venous thrombosis and identify high-risk groups, Gurbey Ocak, M.D., Ph.D., of the Leiden University Medical Center in the Netherlands, and colleagues conducted a case-control study involving 4,311 consecutive patients with a first episode of venous thrombosis and 5,768 controls.

The researchers identified an increased risk of venous thrombosis for all major illnesses, including liver disease (odds ratio [OR], 1.7); (OR, 3.7); rheumatoid arthritis (OR, 1.5); multiple sclerosis (OR, 2.4); (OR, 1.7); (OR, 4.9); arterial thrombosis (OR, 1.5); and in the presence of any of these major illnesses (OR, 1.7). Dramatic increases in the risk of venous thromboembolism were seen for individuals with a combination of major illness plus immobilization and an increased clotting factor VIII (OR, 79.9); elevated factor IX (OR, 35.3); increased von Willebrand factor (OR, 88.0); factor V Leiden (OR, 84.2); or blood group non-O (OR, 84.2).

"These risks were most pronounced at time of immobilization and in the presence of thrombophilia," the authors write. "These results could be a guide for future thromboprophylaxis decisions."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Family history associated with increased risk of blood clots

Mar 23, 2009

Children and siblings of those with venous thrombosis, or blood clots in the veins, appear to have more than double the risk of developing the condition than those without a family history, according to a report in the March ...

Minor leg injuries associated with risk of blood clots

Jan 14, 2008

Muscle ruptures, ankle sprains and other common minor leg injuries appear to be associated with a higher risk for blood clots in the legs or lungs, according to a report in the January 14 issue of Archives of Internal Medicine, ...

Recommended for you

Ebola mistakes should serve a lesson says WHO

18 hours ago

The World Health Organization's chief admitted on Sunday that the UN agency had been caught napping on Ebola, saying it should serve as a lesson to avoid similar mistakes in future.

British Ebola nurse discharged from hospital

Jan 25, 2015

A British nurse who contracted Ebola while working as a volunteer in Sierra Leone said she was "happy to be alive" as she was discharged from hospital on Saturday having made a full recovery.

Tide turning in Ebola fight after hard lessons

Jan 24, 2015

A top U.N. official in the fight against Ebola greeted just three patients at one treatment center he visited this week in Sierra Leone. Families in Liberia are no longer required to cremate the remains of ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.