Third MMR vaccine dose can curtail mumps outbreak

Third MMR vaccine dose can curtail mumps outbreak
Administering a third dose of the measles-mumps-rubella (MMR) vaccine reduced the village-wide attack rate by about 75 percent in a community experiencing a large mumps outbreak despite a high rate of previous MMR vaccination, according to research published online Nov. 5 in Pediatrics.

(HealthDay)—Administering a third dose of the measles-mumps-rubella (MMR) vaccine reduced the village-wide attack rate by about 75 percent in a community experiencing a large mumps outbreak despite a high rate of previous MMR vaccination, according to research published online Nov. 5 in Pediatrics.

Ikechukwu U. Ogbuanu, M.D., M.P.H., Ph.D., of the U.S. in Atlanta, and colleagues offered a third dose of the MMR vaccine to over 2,000 eligible sixth- to 12th-grade students in a religious community in the Northeast affected by a large mumps outbreak, despite high two-dose MMR vaccine coverage.

The researchers found that, overall, 96.2 percent had documentation showing they had received two previous doses of MMR vaccine, and 80.6 percent chose to receive a third vaccine dose. The overall attack rate was statistically significantly reduced, from 4.93 percent before vaccination to 0.13 percent after the third dose was administered. In the village, the overall attack rate was reduced by 75.6 percent after the intervention, with the greatest effects observed in the 11- to 17-year-old age group.

"Our study assessed the use of a third MMR vaccine dose for mumps outbreak control in a setting with preexisting high two-dose ," the authors write. "The findings suggest a potential role of for outbreak control in such limited settings."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Mumps vaccine coverage should be improved, study finds

Aug 24, 2010

Although immunity to mumps is high in the United States, mumps vaccine coverage must be maintained and improved to prevent future outbreaks, according to a new study, now available online, in the September 1, 2010 issue of ...

Mumps outbreak in NY, NJ tops 1,500 cases

Feb 11, 2010

(AP) -- A mumps outbreak among Orthodox Jews in New York and New Jersey has now surpassed 1,500 cases and shows no sign of ending soon, health officials said Thursday.

Recommended for you

Unhealthy brands using Facebook to target young people

16 hours ago

World-first research by the University of Sydney reveals that junk food brands are engaging with young Facebook users to promote unhealthy foods which can contribute to obesity and lifestyle diseases.

Early intervention could boost education levels

16 hours ago

(Medical Xpress)—Taking steps from an early age to improve childhood education skills could raise overall population levels of academic achievement by as much as 5%, and reduce socioeconomic inequality in education by 15%, ...

User comments