Pig tissue scaffolding allows hearts to be rebuilt post-implant

November 13, 2012 by Kevin Hattori
Prof. Marcelle Machluf

(Medical Xpress)—Using tissue from pigs, scientists at the Technion-Israel Institute of Technology have created a "scaffold" that preserves the infrastructure of natural blood vessels and supports human stem cells. The result a rebuilt heart that could be used as a post-heart attack implant.

To create their scaffold, the team led by Prof. Marcelle Machluf, of the Faculty of Biotechnology and Food Engineering, used extracellular matrix proteins, the outer part of animal tissue that, among other functions, provides structural support to cells. They made sure their matrix was as free as possible from components that could provoke immunological rejection, while still retaining its inherent vasculature.

"We used pig heart tissue, as it is physiologically similar to the human heart," said Prof. Machluf. "Its is 98 percent identical to human heart tissue, so the scaffold (and other transplanted pig organs) is not rejected by the ."

Heart attacks are a leading cause of death and disability in the Western world. When they strike, the blood supply to the myocardium (the middle of the three layers forming the wall of the heart) is impaired and, as a result, a scar is formed in the affected area. Since it does not have the ability to pump blood, the significantly burdens the healthy parts of the heart.

Current clinical treatments for heart attacks employ drugs and/or surgery to improve after a heart attack, and to prevent any recurrence. But these treatments cannot change scar tissue into healthy myocardial tissue, so the only current options for end-stage are or pacemakers. Both options are costly and limited in terms of availability.

Use of scaffolds for replacing damaged tissue with healthy transplanted cells should have biomechanical properties that are compatible with those of the myocardium, support the cells and the rehabilitating tissue, provide the required biochemical signals, and break down as the natural extracellular matrix is secreted.

The findings were published in the October issue of Tissue Engineering.

The research was financed by Israel's Office of the Chief Scientist of the Ministry of Industry and Trade and was conducted in cooperation with Singapore's research agency.

Explore further: Genetically engineered cardiac stem cells repaired damaged mouse heart

Related Stories

Recommended for you

Natural compound reduces signs of aging in healthy mice

October 27, 2016

Much of human health hinges on how well the body manufactures and uses energy. For reasons that remain unclear, cells' ability to produce energy declines with age, prompting scientists to suspect that the steady loss of efficiency ...

A metabolic switch to turn off obesity

October 27, 2016

You've tried all the diets. No matter: you've still regained the weight you lost, even though you ate well and you exercised regularly! This may be due to a particular enzyme in the brain: the alpha/beta hydrolase domain-6 ...

Mitochondria control stem cell fate

October 27, 2016

What happens in intestinal epithelial cells during a chronic illness? Basic research conducted at the Chair of Nutrition and Immunology at the Technical University of Munich (TUM) addressed this question by generating a new ...

Scientists develop 'world-first' 3-D mammary gland model

October 27, 2016

A team of researchers from Cardiff University and Monash Biomedicine Discovery Institute has succeeded in creating a three-dimensional mammary gland model that will pave the way for a better understanding of the mechanisms ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.