Smokers leave a history of their addiction in DNA

Researchers at Imperial College London and the Human Genetics Foundation (HuGeF) in Italy have identified a number of sites in the DNA of blood that have been chemically tagged as a result of smoking. These tags are also detectable in lung tissue and could be used to measure the increased risk of certain cancers such as breast and bowel, as well as lung.

Smoking leaves a footprint on the surface of the DNA but the sequence of genetic code remains the same. This is known as an "epigenetic" modification. Once you give up smoking, these tags start to disappear although they never quite match the unmarked DNA of a non-smoker.

In this initial study, measuring DNA tagging in blood samples from smokers and non-smokers allowed the researchers to investigate the link between smoking and these tags. The study also looked at the risk of developing breast and bowel cancer in relation to these DNA tags, with plans to expand the work into other areas such as lung cancer*.

While smoking is associated with bowel cancer risk, a link between smoking and breast cancer has not been proven but the researchers believe that previous studies haven't had the same genetic or epigenetic measures of smoke exposure available. This research will make that information available to scientists so they can spot any DNA tags that might be attributable to any risk that might exist.

Dr James Flanagan, Breast Cancer Campaign scientific fellow at Imperial College London and co-author of the research, said: "This research may help to build a test that will be able to look at a person's epigenetic information at the molecular level and measure in great detail the added risk of cancer from exposures such as smoking.

"Previous research into smoking has often asked people to fill out questionnaires, which have their obvious drawbacks and inaccuracies. Using this approach, we will be able to read the fingerprint on a person's DNA to tell us a story of how their habit may have changed over the course of their life."

Professor Paolo Vineis, chair in environmental epidemiology at Imperial College London's School of Public Health and head of the HuGeF laboratory in Italy, said: "This research will help us to build a molecular profile of cancer risk, where we can screen people and quantify the exposure they've had to a number of risk factors over their lifetime, just by examining a blood sample.

"We hope that smoking is just the start – further work will look into other factors like alcohol and start to measure the risk an individual has built up over a lifetime of exposure to these contributors to cancer."

Dr Jane Cope, director of the NCRI, said: "This is a very interesting piece of research that applies basic biology to everyday life to reveal just how much damage smoking can do to the fundamental biology of a person. If these early results hold true in more detailed studies, this finding could play an important role in understanding smokers' cancer risk in the future."

More information: www.ncri.org.uk/nc… ts/LB94.html

Provided by Cancer Research UK