Teriparatide ups bone union for women with osteoporosis

November 3, 2012
Teriparatide ups bone union for women with osteoporosis
Injections of teriparatide are more effective than oral bisphosphonate for bone union after instrumented lumbar posterolateral fusion in women with postmenopausal osteoporosis, according to a study published in the Nov. 1 issue of Spine.

(HealthDay)—Injections of teriparatide are more effective than oral bisphosphonate for bone union after instrumented lumbar posterolateral fusion in women with postmenopausal osteoporosis, according to a study published in the Nov. 1 issue of Spine.

Seiji Ohtori, M.D., Ph.D., from Chiba University in Japan, and colleagues examined the clinical efficacy of teriparatide for bone union in 57 women with osteoporosis diagnosed with degenerative spondylolisthesis who underwent decompression and one- or two-level instrumented posterolateral fusion with a local . Patients were divided into a teriparatide treatment group (29 patients receiving daily subcutaneous injection of 20 µg teriparatide) or group (28 women receiving weekly oral administration of 17.5 mg of risedronate).

The researchers found that pain scores improved after surgery but that there were no significant between-group differences. In the teriparatide group, the rate of bone union was 82 percent, compared with 68 percent in the bisphosphonate group, and the average duration of bone union was eight and 10 months, respectively. Both the rate of bone union and average duration of bone union were significantly superior in the teriparatide group versus the bisphosphonate group.

"The teriparatide-treated patients showed superior results in the rate of bone union and average duration of bone union compared with the bisphosphonate-treated patients," the authors write. "We think that can enhance in patients with osteoporosis."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Instrumented spinal fusion method impacts infection rate

May 21, 2012

(HealthDay) -- For patients who undergo instrumented spinal fusion, the rates of infection are higher among those who receive posterior lumbar interbody fusion compared with those who receive posterior or posterolateral fusion, ...

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.