U-shaped link for BMI at diagnosis with mortality in T2DM

November 16, 2012
U-shaped link for BMI at diagnosis with mortality in T2DM
For patients with type 2 diabetes mellitus, classification as normal weight or obese within a year of initial diabetes diagnosis correlates with significantly higher mortality, forming a U-shaped association between body mass index and mortality, according to a study published online Nov. 8 in Diabetes Care.

(HealthDay)—For patients with type 2 diabetes mellitus (T2DM), classification as normal weight or obese within a year of initial diabetes diagnosis correlates with significantly higher mortality, forming a U-shaped association between body mass index (BMI) and mortality, according to a study published online Nov. 8 in Diabetes Care.

Jennifer Logue, M.D., of the University of Glasgow in the United Kingdom, and colleagues used data from 106,640 patient records to describe the association between BMI recorded at the time of T2DM diagnosis and mortality.

During a mean follow-up of 4.7 years, the researchers found that the risk of death was significantly higher in patients with a BMI of 20 to <25 kg/m² and patients with a BMI ≥35 kg/m². For each 5-kg/m² increase in BMI above 30 kg/m², the risk of vascular mortality increased by 24 percent for men and 23 percent for women, but was reduced below this threshold. These results were generally similar after adjustment for glycated hemoglobin, year of diagnosis, lipid levels, blood pressure, and patient socioeconomic status.

"Further research is needed to investigate the mechanisms of obesity-related , potential mechanisms for increased mortality at lower BMI, and also the effect of weight loss interventions on morbidity and mortality in people with T2DM with differing levels of baseline BMI," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Lower all-Cause, cardio mortality in obese with RA

May 2, 2012

(HealthDay) -- Overweight and obese patients with rheumatoid arthritis (RA) have lower all-cause and cardiovascular mortality, but have substantially increased risks of comorbidities, medical costs, and reduced quality of ...

Long-term type 2 diabetes ups pancreatic cancer mortality

August 15, 2012

(HealthDay) -- Among patients with pancreatic adenocarcinoma (PAC), those with pre-existing type 2 diabetes mellitus (T2DM) for longer than five years have an increased mortality risk, according to a study published online ...

Recommended for you

Bacteria may cause type 2 diabetes

June 1, 2015

Bacteria and viruses have an obvious role in causing infectious diseases, but microbes have also been identified as the surprising cause of other illnesses, including cervical cancer (Human papilloma virus) and stomach ulcers ...

'Crosstalk' gives clues to diabetes

June 15, 2015

Sometimes, listening in on a conversation can tell you a lot. For Mark Huising, an assistant professor in the Department of Neurobiology, Physiology and Behavior at the UC Davis College of Biological Sciences, that crosstalk ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.