Xeljanz approved for rheumatoid arthritis
November 7, 2012 in Arthritis & Rheumatism
(HealthDay)—Xeljanz (tofacitinib) has been approved by the U.S. Food and Drug Administration to treat symptoms of rheumatoid arthritis (RA) among people who can't tolerate, or haven't been helped by, the drug methotrexate.
RA is an autoimmune disease in which the immune system mistakenly attacks the body. In the case of RA, this leads to swelling of the joints and nearby tissues. About 1.5 million Americans have RA, the FDA said in a news release.
A twice-daily pill, Xeljanz is designed to block molecules involved in joint inflammation, the FDA said.
The drug was evaluated in seven clinical studies of adults with moderate-to-severe RA. The drug carries a "black box" label warning of an increased risk of infection triggered by a suppressed immune system, and tuberculosis and certain cancers.
Other serious side effects could include increased cholesterol levels and liver enzyme problems, the FDA said. More common adverse reactions were upper respiratory tract infections, headaches, diarrhea and nasal inflammation.
Xeljanz is marketed by New York-based Pfizer Inc.
More information: The U.S. National Library of Medicine has more about rheumatoid arthritis.
Copyright © 2012 HealthDay. All rights reserved.
-
FDA panel urges approval for Pfizer arthritis drug
May 09, 2012 |
not rated yet |
0
-
Steroids prevent protein changes seen in the joints of people with rheumatoid arthritis
Jan 27, 2012 |
not rated yet |
0
-
Pfizer says patient died in oral RA drug study
Apr 22, 2011 |
not rated yet |
0
-
Study shows efficacy of new rheumatoid arthritis drug
Aug 09, 2012 |
not rated yet |
0
-
New biologic drug is effective against rheumatoid arthritis
Oct 06, 2009 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
Angular Frequency of AC voltage
3 hours ago
-
Modeling Rigid Body - Unsure about Euler angles and angular velocity
3 hours ago
-
Function for a bullet's path
4 hours ago
-
Elementary questions relating to Newton's laws of motion
6 hours ago
-
Magnetic Energy of Solenoid With/Without Core
6 hours ago
-
Static Equilibrium and D'Alembert's Principle
6 hours ago
- More from Physics Forums - Classical Physics
More news stories
Blame your parents for bunion woes
A novel study reports that white men and women of European descent inherit common foot disorders, such as bunions (hallux valgus) and lesser toe deformities, including hammer or claw toe. Findings from the Framingham Foot ...
Arthritis & Rheumatism
22 hours ago |
not rated yet |
0
|
New theory on genesis of osteoarthritis comes with successful therapy in mice
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
Arthritis & Rheumatism
May 19, 2013 |
4.8 / 5 (6) |
0
|
Ultrasound findings can improve classification of RA
(HealthDay)—Compared to clinical diagnosis of synovitis, ultrasound-detected synovitis provides either improved sensitivity or specificity when used with the American College of Rheumatology/European League ...
Arthritis & Rheumatism
May 15, 2013 |
not rated yet |
0
Strong genetic component of fibromyalgia suggested
(HealthDay)—A genome-wide linkage scan has identified the chromosome 17p11.2-q11.2 region as the susceptibility locus for fibromyalgia, according to research published in the April issue of Arthritis & ...
Arthritis & Rheumatism
May 11, 2013 |
not rated yet |
0
Discovery shows fat triggers rheumatoid arthritis
Scientists have discovered that fat cells in the knee secrete a protein linked to arthritis, a finding that paves the way for new gene therapies that could offer relief and mobility to millions worldwide.
Arthritis & Rheumatism
May 08, 2013 |
5 / 5 (5) |
0
|
Early-life traffic-related air pollution exposure linked to hyperactivity
Early-life exposure to traffic-related air pollution was significantly associated with higher hyperactivity scores at age 7, according to new research from the University of Cincinnati (UC) and Cincinnati Children's Hospital ...
Resistance to last-line antibiotic makes bacteria resistant to immune system
Bacteria resistant to the antibiotic colistin are also commonly resistant to antimicrobial substances made by the human body, according to a study in mBio, the online open-access journal of the American Society for Microb ...
New immune system discovered
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.
The compound in the Mediterranean diet that makes cancer cells 'mortal'
New research suggests that a compound abundant in the Mediterranean diet takes away cancer cells' "superpower" to escape death. By altering a very specific step in gene regulation, this compound essentially re-educates cancer ...
Scientists identify molecular trigger for Alzheimer's disease
Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons ...
Do salamanders hold the solution to regeneration?
Salamanders' immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have ...
