Antimicrobial resistance up in K. pneumoniae isolates

Antimicrobial resistance up in <i>K. pneumoniae</i> isolates
Klebsiella pneumoniae isolates from U.S. inpatients are becoming increasingly resistant to antimicrobial agents, according to a study published in the January issue of Emerging Infectious Diseases.

(HealthDay)—Klebsiella pneumoniae (K. pneumoniae) isolates from U.S. inpatients are becoming increasingly resistant to antimicrobial agents, according to a study published in the January issue of Emerging Infectious Diseases.

Guillermo V. Sanchez, M.D., of the George Washington University in Washington, D.C., and colleagues used data from The Surveillance Network to examine trends in antimicrobial-resistant K. pneumoniae among U.S. inpatients from 1998 to 2010.

Data on antimicrobial susceptibility were available for 3,132,354 specimens collected from blood, sputum, urine, and wounds. The researchers found that imipenem resistance was first noted in 2004, and increased gradually to 4.3 percent by 2010. During the study period, changes in K. pneumoniae varied, ranging from large increases for aztreonam (7.7 to 22.2 percent), ceftazidime (5.5 to 17.2 percent), and (5.5 to 16.8 percent), and smaller increases for tetracycline (14.2 to 16.7 percent) and amikacin (0.7 to 4.5 percent). In 2010, for all antimicrobial agents except tetracycline, higher levels of drug resistance were found in isolates from the versus urine. Isolates of K. pneumonia resistant to imipenem exhibited the least resistance to tetracycline (19.9 percent) and amikacin (36.8 percent), and a high prevalence of cross resistance was found for ciprofloxacin (96.4 percent).

"Our study shows that K. pneumoniae antimicrobial drug resistance increased for every antimicrobial class studied except tetracyclines," the authors write. "This emerging problem presents a major threat to public health and warrants due diligence in future surveillance efforts."

More information: Full Text

add to favorites email to friend print save as pdf

Related Stories

European league-tables for antibiotic resistance revealed

Jul 08, 2008

Tests of antibiotic resistance in cattle have revealed stark variation across thirteen European countries. The results, published today in BioMed Central’s open-access journal Acta Veterinaria Scandinavica, show that major ...

'Resuscitating' antibiotics to overcome drug resistance

Mar 28, 2012

Combining common antibiotics with additional compounds could make previously resistant bacteria more susceptible to the same antibiotics. 'Resuscitation' of existing antibiotics has the potential to make infections caused ...

Recommended for you

Travel restrictions could worsen Ebola crisis: experts

7 minutes ago

Travel restrictions could worsen West Africa's Ebola epidemic, limiting medical and food supplies and keeping out much-needed doctors, virologists said Tuesday as the disease continued its deadly spread.

World 'losing the battle' to contain Ebola: MSF

47 minutes ago

International medical agency Medecins sans Frontieres said Tuesday the world was "losing the battle" to contain Ebola and called for a global biological disaster response to get aid and personnel to west Africa.

Mutating Ebola viruses not as scary as evolving ones

1 hour ago

My social media accounts today are cluttered with stories about "mutating" Ebola viruses. The usually excellent ScienceAlert, for example, rather breathlessly informs us "The Ebola virus is mutating faster in humans than in animal hosts ...

War between bacteria and phages benefits humans

2 hours ago

In the battle between our immune systems and cholera bacteria, humans may have an unknown ally in bacteria-killing viruses known as phages. In a new study, researchers from Tufts University, Massachusetts ...

Ebola kills 31 people in DR Congo: WHO

3 hours ago

An outbreak of the Ebola virus in the Democratic Republic of Congo has killed 31 people and the epidemic remains contained in a remote northwestern region, UN the World Health Organization (WHO) said Tuesday.

User comments