Antimicrobial resistance up in K. pneumoniae isolates

December 20, 2012
Antimicrobial resistance up in <i>K. pneumoniae</i> isolates
Klebsiella pneumoniae isolates from U.S. inpatients are becoming increasingly resistant to antimicrobial agents, according to a study published in the January issue of Emerging Infectious Diseases.

(HealthDay)—Klebsiella pneumoniae (K. pneumoniae) isolates from U.S. inpatients are becoming increasingly resistant to antimicrobial agents, according to a study published in the January issue of Emerging Infectious Diseases.

Guillermo V. Sanchez, M.D., of the George Washington University in Washington, D.C., and colleagues used data from The Surveillance Network to examine trends in antimicrobial-resistant K. pneumoniae among U.S. inpatients from 1998 to 2010.

Data on antimicrobial susceptibility were available for 3,132,354 specimens collected from blood, sputum, urine, and wounds. The researchers found that imipenem resistance was first noted in 2004, and increased gradually to 4.3 percent by 2010. During the study period, changes in K. pneumoniae varied, ranging from large increases for aztreonam (7.7 to 22.2 percent), ceftazidime (5.5 to 17.2 percent), and (5.5 to 16.8 percent), and smaller increases for tetracycline (14.2 to 16.7 percent) and amikacin (0.7 to 4.5 percent). In 2010, for all antimicrobial agents except tetracycline, higher levels of drug resistance were found in isolates from the versus urine. Isolates of K. pneumonia resistant to imipenem exhibited the least resistance to tetracycline (19.9 percent) and amikacin (36.8 percent), and a high prevalence of cross resistance was found for ciprofloxacin (96.4 percent).

"Our study shows that K. pneumoniae antimicrobial drug resistance increased for every antimicrobial class studied except tetracyclines," the authors write. "This emerging problem presents a major threat to public health and warrants due diligence in future surveillance efforts."

Explore further: European league-tables for antibiotic resistance revealed

More information: Full Text

Related Stories

European league-tables for antibiotic resistance revealed

July 8, 2008

Tests of antibiotic resistance in cattle have revealed stark variation across thirteen European countries. The results, published today in BioMed Central’s open-access journal Acta Veterinaria Scandinavica, show that major ...

'Resuscitating' antibiotics to overcome drug resistance

March 28, 2012

Combining common antibiotics with additional compounds could make previously resistant bacteria more susceptible to the same antibiotics. 'Resuscitation' of existing antibiotics has the potential to make infections caused ...

Recommended for you

Immune breakthrough: Unscratching poison ivy's rash

August 23, 2016

We all know that a brush with poison ivy leaves us with an itchy painful rash. Now, Monash University and Harvard researchers have discovered the molecular cause of this irritation. The finding brings us a step closer to ...

Zika infection may affect adult brain cells

August 18, 2016

Concerns over the Zika virus have focused on pregnant women due to mounting evidence that it causes brain abnormalities in developing fetuses. However, new research in mice from scientists at The Rockefeller University and ...

Monkeys with Sudan ebolavirus treated successfully

August 22, 2016

Scientists funded by the National Institutes of Health (NIH) have successfully treated monkeys several days after the animals were infected with Sudan ebolavirus (SUDV). The study is important, according to the researchers, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.