Cabozantinib active in castration-resistant prostate cancer

Cabozantinib active in castration-resistant prostate cancer
The orally bioavailable tyrosine kinase inhibitor cabozantinib (XL184) has clinical activity in men with castration-resistant prostate cancer, according to a study published online Nov. 19 in the Journal of Clinical Oncology.

(HealthDay)—The orally bioavailable tyrosine kinase inhibitor cabozantinib (XL184) has clinical activity in men with castration-resistant prostate cancer (CRPC), according to a study published online Nov. 19 in the Journal of Clinical Oncology.

David C. Smith, M.D., of the University of Michigan in Ann Arbor, and colleagues conducted a phase II randomized discontinuation trial involving 171 men with CRPC to evaluate the activity of cabozantinib. Patients received 100 mg of cabozantinib each day, and those with stable disease at 12-weeks were randomized to receive cabozantinib or placebo.

Based on the observed activity of cabozantinib, random assignment was stopped early. The researchers found that 72 percent of patients had regression in soft tissue lesions and 68 percent exhibited improvement on bone scan, including 12 percent with complete resolution. At 12 weeks, the objective response rate was 5 percent, and 75 percent exhibited stable disease. The median progression-free survival was 23.9 and 5.9 weeks for cabozantinib- and placebo-treated patients, respectively (hazard ratio, 0.12). In 57 percent of patients, there was a reduction of at least 50 percent in serum total and plasma cross-linked C-terminal telopeptide of type I collagen. In a retrospective data review, bone pain was improved for 67 percent of patients, and narcotic use decreased by 56 percent. Fatigue, hypertension, and hand-foot syndrome were the most common grade 3 adverse events.

"Cabozantinib has substantial in patients with advanced CRPC with manageable toxicity consistent with other targeting multiple pathways," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Exelixis, which manufactures cabozantinib and supported the study.

More information: Abstract
Full Text

add to favorites email to friend print save as pdf

Related Stories

Tivozanib exhibits antitumor activity in renal cancer

Apr 10, 2012

(HealthDay) -- The potent, selective vascular endothelial growth factor receptor-1, -2, and -3 inhibitor, tivozanib, demonstrates antitumor activity and is well tolerated in patients with advanced/metastatic ...

Regorafenib active in metastatic GI stromal tumors

May 23, 2012

(HealthDay) -- Regorafenib, an inhibitor of multiple cancer-associated kinases, is active in patients with metastatic gastrointestinal stromal tumors (GIST) who have failed to respond to imatinib and sunitinib, ...

Cetuximab, paclitaxel combo active in urothelial cancer

Aug 29, 2012

(HealthDay)—The monoclonal antibody against epidermal growth factor receptor (EGFR), cetuximab, augments the antitumor activity of paclitaxel in patients with previously treated urothelial cancer, according ...

Recommended for you

US OKs first-ever DNA alternative to Pap smear (Update 2)

9 hours ago

U.S. government health regulators have cleared a genetic test from Roche as a first-choice screening option for cervical cancer. It was a role previously reserved for the Pap smear, the decades-old mainstay of women's health.

New breast cancer imaging method promising

15 hours ago

The new PAMmography method for imaging breast cancer developed by the University of Twente's MIRA research institute and the Medisch Spectrum Twente hospital appears to be a promising new method that could ...

Palliation is rarely a topic in studies on advanced cancer

15 hours ago

End-of-life aspects, the corresponding terminology, and the relevance of palliation in advanced cancer are often not considered in publications on randomized controlled trials (RCTs). This is the result of an analysis by ...

User comments