Congenital heart defects could have their origin during very early pregnancy
The origins of congenital heart defects could be traced right back to the first stages of embryonic development, according to University of East Anglia (UEA) research.
Findings published today in the journal PLOS ONE show that the beginnings of important parts of the heart can be traced to very early stages of embryo development. The research has been funded by the British Heart Foundation.
Biologists investigated chicken eggs at the gastrulation stage - between 12 and 14 hours after fertilisation.
They found that some cells would go on to create the anterior and secondary heart fields - after the initial formation of a primitive linear heart tube.
This method of understanding the correlation between the embryonic origin of cells and later stages of development is called 'fate mapping'.
The addition of these early cells to the growing heart is crucial as it allows the heart to develop and form other important structures including the outflow tract.
The research is the first to 'fate map' the origin of the cells which contribute to the outflow tract in early stage embryos.
Many cardiac malformations present in newborns are associated with the outflow tract and it is hoped that understanding some of the underlying causes may be helpful to affected families.
Prof Andrea Münsterberg, from the school of Biological Sciences at UEA, said: "We were researching chick embryos, but the process of development in humans is very similar. However while the gastrulation stage takes place within just a few hours in chicks, it takes a little longer in humans and happens in the third week of pregnancy.
"It is likely that what we learn in chick embryos can be applied to human development. The next step in our research will be to identify the factors, which guide these early cardiac progenitor cells to the right place at the correct time."
More information: 'Fate mapping identifies the origin of SHF/AHF progenitors in the chick primitive streak' by Esther Camp (UEA), Susanne Dietrich (University of Portsmouth) and Andrea Münsterberg (UEA) is published by PLOS ONE on December 13, 2012. dx.plos.org/10.137… pone.0051948
Journal reference: PLoS ONE
Provided by University of East Anglia
- Frog embryo research leads to new understanding of cardiac development Apr 22, 2011 | not rated yet | 0
- Researchers identify key mechanism that guides cells to form heart tissue Mar 17, 2010 | not rated yet | 0
- Distinct chromatin patterns linked to heart development Sep 17, 2012 | not rated yet | 0
- Researchers examine developing hearts in chickens to find solutions for human heart abnormalities (Video) Jan 21, 2009 | not rated yet | 0
- Study identifies second gene associated with specific congenital heart defects Apr 29, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Electric field between parallel plate capacitor
41 minutes ago If you have an infinite non-conducting plate, the electric field just outside is equal to sigma / 2*epsilon. The electric field just outside a...
Why angle of projectile has 2 solutions?
1 hour ago I have the final answer of: sin2(theta) = 0.871 why does (theta) = 30.3 deg OR (theta) = 59.7 deg I get why this could be physically, but...
How much negative charge do I accumulate by touching the earth?
2 hours ago The Earth carries a negative electric charge of roughly 500 thousand Coulombs (according to different sources I've seen). If I touch the Earth I...
Indeterminism in Classical Physics
8 hours ago I was reading the Roger Penrose book Emperor's New Mind and he was explaining the determinism in Newtonian mechanics. He says that if we consider...
Current in two wires
8 hours ago Wire A and B, which have the same cross-sectional area are connected in series. There is a p.d. V across the whole wire. Suppose the two wires...
understanding the dipole model for Rayleigh scattering
10 hours ago Hello. I am currently studying scattering theory in detail for my BSc thesis, and I'm starting with Rayleigh scattering. I'm following Scattering...
- More from Physics Forums - Classical Physics
More news stories
Transcatheter aortic valve implantation (TAVI) is effective and safe in Asian patients, according to early experience based on first results from a multicentre Asian registry reported at EuroPCR 2013.
Cardiology 3 hours ago | not rated yet | 0
Routinely measuring fractional flow reserve (FFR) using pressure wire assessment during coronary angiography for diagnosis of chest pain leads to significant changes in the management of one in four patients, according to ...
Cardiology 6 hours ago | not rated yet | 0
A new investigational device - the Helio System (TF-FA) - being developed for use with the Sapien XT Transcatheter Heart Valve was successfully deployed in all four patients in a small, first-in-human feasibility study of ...
Cardiology 6 hours ago | not rated yet | 0
Cardiac study used as source for new guidelines on treating people undergoing coronary artery bypass surgery
Cardiac research from the University of Alberta had serious impact as a source for the American College of Cardiology and the American Heart Association's new guidelines on how to treat patients undergoing coronary artery ...
Cardiology 7 hours ago | not rated yet | 0
(HealthDay)—In patients who have previously been considered difficult to image, dual-source cardiac (DSC) computed tomography (CT) can identify clinically significant coronary artery disease, according ...
Cardiology 20 hours ago | not rated yet | 0
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
22 minutes ago | not rated yet | 0 |
(AP)—Government health officials are investigating several health problems reported with potentially contaminated medications made by a Tennessee specialty pharmacy.
17 minutes ago | not rated yet | 0
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
6 hours ago | 5 / 5 (3) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
2 hours ago | 5 / 5 (1) | 0 |
Kate O'Reilly's spring allergy survival kit includes the usual stuff - nasal sprays, allergy pills and a box of tissues. This season, she's added a new weapon to her line of defense: an app on her smartphone.
1 hour ago | not rated yet | 0
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
3 hours ago | 5 / 5 (2) | 0 |