The X factor in liver metabolism

December 21, 2012

After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway contributes to the liver's metabolic switch.

In this issue of the , researchers led by Phillip Scherer at the University of Texas Southwestern Medical Center report that activation of the UPR triggers the expression of Xbp1s, a protein that regulates genes needed for the metabolic switch. Scherer and colleagues found that they could induce changes in just by increasing expression of Xbps1.

These results suggest that Xbps1 could play a role in metabolic disease.

Explore further: Secreted protein sends signal that fat is on the way

More information: The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism, Journal of Clinical Investigation, 2012.

Related Stories

Secreted protein sends signal that fat is on the way

December 2, 2008

After you eat a burger and fries or other fat-filled meal, a protein produced by the liver may send a signal that fat is on the way, suggests a report in the December issue of the journal Cell Metabolism, a Cell Press publication.

Cellular stress causes fatty liver disease in mice

December 8, 2008

A University of Iowa researcher and colleagues at the University of Michigan have discovered a direct link between disruption of a critical cellular housekeeping process and fatty liver disease, a condition that causes fat ...

In obesity, a micro-RNA causes metabolic problems

September 20, 2012

Scientists have identified a key molecular player in a chain of events in the body that can lead to fatty liver disease, Type II diabetes and other metabolic abnormalities associated with obesity. By blocking this molecule, ...

Endotrophin links obesity to breast cancer progression

October 8, 2012

Fat cells (adipocytes) surround breast tumors and contribute to tumor growth by expressing factors that aid oncogenesis. Col6 is a protein that is highly expressed in adipocytes and its expression is further increased in ...

Recommended for you

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.