Gene-environment interaction ups risk of preeclampsia

December 10, 2012 in Health

Gene-environment interaction ups risk of preeclampsia

A genetic variant, AGT2R, in mothers, fathers, and neonates is associated with a significantly increased risk of preeclampsia in mothers with a body mass index of 25 kg/m² or more, according to a study published online Nov. 5 in Placenta.

(HealthDay)—A genetic variant, AGT2R, in mothers, fathers, and neonates is associated with a significantly increased risk of preeclampsia in mothers with a body mass index (BMI) of 25 kg/m² or more, according to a study published online Nov. 5 in Placenta.

Ang Zhou, M.D., from the University of Adelaide in Australia, and colleagues analyzed data from 2,121 Caucasian parent-infant trios, 123 of whom had preeclamptic pregnancies; 1,185 uncomplicated pregnancies served as controls. DNA was extracted from buffy coats and genotyped for polymorphisms in AGT1R and AGT2R. Doppler sonography was performed at 20 weeks of gestation on the uterine arteries.

The researchers identified four polymorphisms in AGT1R and AGT2R genes (AGT1R A1166C, AGT2R C4599A, AGT2R A1675G, and AGT2R T1134C), with significant associations observed for AGT2R C4599A. For women with BMI ≥25 kg/m², maternal and neonatal AGT2R C4599A AA versus CC genotype correlated with an increased risk for (adjusted odds ratio [aOR], 2.1 and 3.0, respectively). In the same subset of women, the paternal AGT2R C4599A A allele versus the C allele correlated with an increased risk for preeclampsia and uterine artery bilateral notching at 20 weeks of gestation (aOR, 1.9 and 2.1, respectively).

"AGT2R C4599A in mothers, fathers, and babies was associated with preeclampsia and this association was only apparent in pregnancies in which the women had a BMI ≥25 kg/m², suggesting a gene-environment interaction," Zhou and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.

not rated yet  

Rank not rated yet
Related Stories
Relevant PhysicsForums posts

More news stories

Driving and hands-free talking lead to spike in errors, study shows

Talking on a hands-free device while behind the wheel can lead to a sharp increase in errors that could imperil other drivers on the road, according to new research from the University of Alberta.

Health created 19 hours ago | popularity not rated yet | comments 0

About one in four uninsured could be excluded from ACA

(HealthDay)—More than one in four of those eligible for new premium assistance tax credits under the Affordable Care Act (ACA) do not have a checking account and will not be able to receive premiums from ...

Health created 21 hours ago | popularity not rated yet | comments 0

Audiologists recommend smart phone apps to monitor noise levels

After studying noise in one French Quarter neighborhood of New Orleans to determine whether or not noise levels exceeded municipal ordinances, Annette Hurley, PhD, Assistant Professor of Audiology at LSU Health Sciences Center ...

Health created 22 hours ago | popularity not rated yet | comments 0

Young children who miss well-child visits are more likely to be hospitalized

Young children who missed more than half of recommended well-child visits had up to twice the risk of hospitalization compared to children who attended most of their visits, according to a study published today in the American Jo ...

Health created 23 hours ago | popularity not rated yet | comments 0

Do doctors understand the individualisation of treatments?

The individualisation of drug treatments to support patients to self-manage their conditions is a concept that sits at the heart of policy, but a recent study in BMJ Open shows that there is no concrete defini ...

Health created May 24, 2013 | popularity 3 / 5 (1) | comments 0


First drug to improve heart failure mortality in over a decade

Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...

Hormone levels may provide key to understanding psychological disorders in women

Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.

Heart failure accelerates male 'menopause'

Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...

Researchers identify first drug targets in childhood genetic tumor disorder

Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...

Going live: Immune cell activation in multiple sclerosis

Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...

Feds fight morning-after pill age ruling in NY

(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...