Research shows immune system response is detrimental to novel brain cancer therapy

December 4, 2012

For the first time, researchers have demonstrated that the response of natural killer (NK) cells is detrimental to glioblastoma virotherapy, a novel way of treating malignant brain cancer by injecting a virus into the tumor. A number of clinical trials are currently underway to test whether glioblastoma virotherapy will facilitate antitumor efficacy, but research led by E. Antonio Chiocca, MD, PhD, chairman of the Department of Neurosurgery at Brigham and Women's Hospital, and published in Nature Medicine, shows that in pre-clinical models, NK cells are killing off the virus – infected cells, thus rendering the therapy less effective.

"This situation is similar to injecting a beneficial drug into a human and the drug is killed off because humans have an antibody against the drug," said Dr. Chiocca, the senior author of the research paper. "This finding will be of great interest to those who are studying experimental biology and tumors of the brain, as well as to patients with ."

Dr. Chiocca hypothesizes that temporarily suppressing the immune system of glioblastoma patients on a short-term basis could counteract this response and allow the virotherapy work. The study may also expose novel targets to enhance therapy.For more information on the study, the entire manuscript, "NK cells impede glioblastoma virotherapy via NKp30 and NKp46 natural cytotoxicity receptors", is available in Nature Medicine.

Related Stories

A culprit behind brain tumor resistance to therapy

March 5, 2012

Persistent protein expression may explain why tumors return after therapy in glioblastoma patients, according to a study published on March 5th in the Journal of Experimental Medicine.

Recommended for you

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.