Raised risk of ischemic stroke in women with A-fib explored

Raised risk of ischemic stroke in women with A-fib explored
Women with atrial fibrillation (AF) have a higher risk of ischemic stroke than men with AF, related in part to differences in the percent time in the therapeutic range (TTR) associated with warfarin anticoagulation control, according to research published in the Dec. 15 issue of The American Journal of Cardiology.

(HealthDay)—Women with atrial fibrillation (AF) have a higher risk of ischemic stroke than men with AF, related in part to differences in the percent time in the therapeutic range (TTR) associated with warfarin anticoagulation control, according to research published in the Dec. 15 issue of The American Journal of Cardiology.

To determine the incidence of by gender and the impact of TTR on the correlation between gender and ischemic stroke, Renee M. Sullivan, M.D., of the University of Iowa in Iowa City, and colleagues used data from the Atrial Fibrillation Follow-up Investigation of Rhythm Management trial involving 4,060 patients with AF.

The researchers found that, compared with men, women had significantly higher , hypertension, age ≥75 years, diabetes mellitus, prior stroke, , or thromboembolism scores and more ischemic strokes compared with men (5 versus 3 percent; odds ratio, 1.60). For women versus men, significantly more time was spent outside the therapeutic range (40 versus 37 percent) and below the therapeutic range (29 versus 26 percent). For women, but not men, a higher TTR protected against ischemic stroke. Significantly more ischemic strokes were seen for women with a comparably high TTR (≥66 percent). Gender, having a TTR less than 46 percent versus higher than 80 percent, age, and previous stroke all correlated significantly with .

"The major new finding in this analysis is that a lower TTR partly explains the increased risk of stroke in women compared to men, although even after adjustment for this factor women continued to be at increased risk," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Kidney disease increases the risk of stroke in patients

Mar 04, 2009

Chronic kidney disease increases the risk of stroke in patients with atrial fibrillation (AF), the most common type of heart arrhythmia, according to a new study by Kaiser Permanente researchers in the current online issue ...

Recommended for you

Gene variant raises risk for aortic tear and rupture

17 hours ago

Researchers from Yale School of Medicine and Celera Diagnostics have confirmed the significance of a genetic variant that substantially increases the risk of a frequently fatal thoracic aortic dissection or full rupture. ...

Considerable variation in CT use in ischemic stroke

17 hours ago

(HealthDay)—For patients with ischemic stroke there is considerable variation in the rates of high-intensity computed tomography (CT) use, according to a study published online April 8 in Circulation: Ca ...

Beating the clock for ischemic stroke sufferers

Apr 17, 2014

A ground-breaking computer technology raises hope for people struck by ischemic stroke, which is a very common kind of stroke accounting for over 80 per cent of overall stroke cases. Developed by research experts at The Hong ...

Risk for nonelective thoracic aortic sx up for uninsured

Apr 16, 2014

(HealthDay)—Uninsured patients have an increased risk of nonelective thoracic aortic operations, and have increased risks of major morbidity or mortality, according to a study published online April 8 in ...

User comments