Raised risk of ischemic stroke in women with A-fib explored

December 10, 2012
Raised risk of ischemic stroke in women with A-fib explored
Women with atrial fibrillation (AF) have a higher risk of ischemic stroke than men with AF, related in part to differences in the percent time in the therapeutic range (TTR) associated with warfarin anticoagulation control, according to research published in the Dec. 15 issue of The American Journal of Cardiology.

(HealthDay)—Women with atrial fibrillation (AF) have a higher risk of ischemic stroke than men with AF, related in part to differences in the percent time in the therapeutic range (TTR) associated with warfarin anticoagulation control, according to research published in the Dec. 15 issue of The American Journal of Cardiology.

To determine the incidence of by gender and the impact of TTR on the correlation between gender and ischemic stroke, Renee M. Sullivan, M.D., of the University of Iowa in Iowa City, and colleagues used data from the Atrial Fibrillation Follow-up Investigation of Rhythm Management trial involving 4,060 patients with AF.

The researchers found that, compared with men, women had significantly higher , hypertension, age ≥75 years, diabetes mellitus, prior stroke, , or thromboembolism scores and more ischemic strokes compared with men (5 versus 3 percent; odds ratio, 1.60). For women versus men, significantly more time was spent outside the therapeutic range (40 versus 37 percent) and below the therapeutic range (29 versus 26 percent). For women, but not men, a higher TTR protected against ischemic stroke. Significantly more ischemic strokes were seen for women with a comparably high TTR (≥66 percent). Gender, having a TTR less than 46 percent versus higher than 80 percent, age, and previous stroke all correlated significantly with .

"The major new finding in this analysis is that a lower TTR partly explains the increased risk of stroke in women compared to men, although even after adjustment for this factor women continued to be at increased risk," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Heart attack treatment hypothesis 'busted'

July 6, 2015

Researchers have long had reason to hope that blocking the flow of calcium into the mitochondria of heart and brain cells could be one way to prevent damage caused by heart attacks and strokes. But in a study of mice engineered ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.