Liver transplant outcomes no worse with echo abnormalities

December 7, 2012
Liver transplant outcomes no worse with echo abnormalities
Intracardiac shunts, diagnosed using an echocardiogram, or mild or moderate pulmonary hypertension, do not affect short- or long-term mortality in liver transplant candidates, according to research published online in the Dec. 15 issue of The American Journal of Cardiology.

(HealthDay)—Intracardiac shunts (ICSs), diagnosed using an echocardiogram, or mild or moderate pulmonary hypertension (PH), do not affect short- or long-term mortality in liver transplant candidates, according to research published online in the Dec. 15 issue of The American Journal of Cardiology.

Matthew E. Harinstein, M.D., of the University of Pittsburgh Medical Center, and colleagues conducted a involving 502 consecutive patients (318 men) with end-stage liver disease who had echocardiography prior to . Contrast echocardiography was used to diagnose ICSs, and PH was defined as pulmonary artery systolic pressure >40 mm Hg.

The researchers found that more than 50 percent of the study population had at least two : ICSs were found in 16 percent, PH in 25 percent, and intrapulmonary shunts in 41 percent of liver transplant candidates. Short-(30-day) and long-term (mean, 41 months) mortality was not associated with ICSs or PH. Furthermore, no strokes occurred in those with ICSs.

"In conclusion, structural differences exist between various end-stage liver disease diagnoses. ICSs diagnosed by echocardiography are not associated with an increased risk of perioperative stroke or increased mortality. A diagnosis of mild or moderate PH on baseline echocardiogram is not associated with worse outcomes and requires further assessment," the authors write. "Based on these findings, patients should not be excluded from consideration for liver transplantation based solely on the presence of an ICS or PH."

Explore further: Liver transplant offers survival benefits for patients of all sizes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Immune breakthrough: Unscratching poison ivy's rash

August 23, 2016

We all know that a brush with poison ivy leaves us with an itchy painful rash. Now, Monash University and Harvard researchers have discovered the molecular cause of this irritation. The finding brings us a step closer to ...

Zika infection may affect adult brain cells

August 18, 2016

Concerns over the Zika virus have focused on pregnant women due to mounting evidence that it causes brain abnormalities in developing fetuses. However, new research in mice from scientists at The Rockefeller University and ...

Monkeys with Sudan ebolavirus treated successfully

August 22, 2016

Scientists funded by the National Institutes of Health (NIH) have successfully treated monkeys several days after the animals were infected with Sudan ebolavirus (SUDV). The study is important, according to the researchers, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.