Predictors of organ damage identified in patients with SLE

December 16, 2012
Predictors of organ damage identified in patients with SLE
Patient age, hypertension, and corticosteroid use are the most important predictors of the cumulative organ damage that occurs in patients with systemic lupus erythematosus, according to research published in the December issue of Arthritis & Rheumatism.

(HealthDay)—Patient age, hypertension, and corticosteroid use are the most important predictors of the cumulative organ damage that occurs in patients with systemic lupus erythematosus (SLE), according to research published in the December issue of Arthritis & Rheumatism.

Michelle Petri, M.D., M.P.H., of the Johns Hopkins University School of Medicine in Baltimore, and colleagues used data from 2,054 patients with SLE in the Hopkins Cohort in an effort to identify predictors of organ damage, as assessed by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index (SDI).

The researchers found that the rate of increase of the SDI score was 0.13 per year. African-American, male, or older patients as well as those with lower income or educational levels had higher rates of damage. Additionally, SLE patients with , proteinuria, or who were positive for lupus anticoagulant had increased rates of organ damage. During follow-up, those who were older, received corticosteroids, had more disease activity, satisfied more ACR criteria for SLE, had low complement levels, or who were positive for anti-double-stranded DNA had a higher risk of organ damage. Of these factors, age, hypertension, and corticosteroid use were the most important predictors of cumulative in SLE patients. Lower risk was seen for patients receiving hydroxychloroquine.

"Our findings indicate that rates of damage vary in demographic subgroups, but much variation appears to be explained by hypertension and use," the authors write. "These data clearly point to the need for tight control of disease activity without reliance on corticosteroids."

Explore further: Smokers with common autoimmune disorder at higher risk for skin damage

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Back pain link to 24-hour body clock revealed

August 4, 2016

New research by University of Manchester scientists has for the first time shown that our spinal discs have 24-hour body clocks which when they malfunction, can contribute to lower back pain.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.