Predictors of organ damage identified in patients with SLE

December 16, 2012
Predictors of organ damage identified in patients with SLE
Patient age, hypertension, and corticosteroid use are the most important predictors of the cumulative organ damage that occurs in patients with systemic lupus erythematosus, according to research published in the December issue of Arthritis & Rheumatism.

(HealthDay)—Patient age, hypertension, and corticosteroid use are the most important predictors of the cumulative organ damage that occurs in patients with systemic lupus erythematosus (SLE), according to research published in the December issue of Arthritis & Rheumatism.

Michelle Petri, M.D., M.P.H., of the Johns Hopkins University School of Medicine in Baltimore, and colleagues used data from 2,054 patients with SLE in the Hopkins Cohort in an effort to identify predictors of organ damage, as assessed by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index (SDI).

The researchers found that the rate of increase of the SDI score was 0.13 per year. African-American, male, or older patients as well as those with lower income or educational levels had higher rates of damage. Additionally, SLE patients with , proteinuria, or who were positive for lupus anticoagulant had increased rates of organ damage. During follow-up, those who were older, received corticosteroids, had more disease activity, satisfied more ACR criteria for SLE, had low complement levels, or who were positive for anti-double-stranded DNA had a higher risk of organ damage. Of these factors, age, hypertension, and corticosteroid use were the most important predictors of cumulative in SLE patients. Lower risk was seen for patients receiving hydroxychloroquine.

"Our findings indicate that rates of damage vary in demographic subgroups, but much variation appears to be explained by hypertension and use," the authors write. "These data clearly point to the need for tight control of disease activity without reliance on corticosteroids."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Team finds gene that confirms existence of psoriatic arthritis

February 5, 2015

PsA is a common form of inflammatory form of arthritis causing pain and stiffness in joints and tendons that can lead to joint damage. Nearly all patients with PsA also have skin psoriasis and, in many cases, the skin disease ...

Blocking one receptor could halt rheumatoid arthritis

September 10, 2014

Researchers at the University of Illinois at Chicago College of Medicine have shown for the first time how the activation of a receptor provokes the inflammation and bone degradation of rheumatoid arthritis—and that activation ...

Low back pain? Don't blame the weather

July 10, 2014

Australian researchers reveal that sudden, acute episodes of low back pain are not linked to weather conditions such as temperature, humidity, air pressure, wind direction and precipitation. Findings published in Arthritis ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.