Sequential CT screening can identify indolent lung cancers
Changes in size on sequential low-dose computed tomography screenings, expressed as volume doubling time, indicate that about 25 percent of progressive lung cancers are slow growing or indolent, with higher lung cancer-specific mortality for new versus slow-growing or indolent cancers, according to a study published in the Dec. 4 issue of the Annals of Internal Medicine.
(HealthDay)—Changes in size on sequential low-dose computed tomography (LDCT) screenings, expressed as volume doubling time (VDT), indicate that about 25 percent of progressive lung cancers are slow growing or indolent, with higher lung cancer-specific mortality for new versus slow-growing or indolent cancers, according to a study published in the Dec. 4 issue of the Annals of Internal Medicine.
Giulia Veronesi, M.D., from the European Institute of Oncology in Milan, and colleagues assessed VDT as an indicator of overdiagnosis for screening-detected lung cancer by estimating the VDT in 175 high-risk patients who were diagnosed with primary lung cancer. VDT was characterized as fast growing (VDT <400 days), slow growing (VDT between 400 and 599 days), or indolent (VDT ≥600 days).
Within the cohort, 55 cases of cancer were diagnosed at baseline and 120 were diagnosed subsequently. Of the later group, the researchers found that 15.8 percent of tumors were not visible on previous scans and were classified as fast growing (median VDT 52 days); 84.2 percent were progressive (58.3 percent fast growing and 25.8 percent slow growing [15.0 percent] or indolent [10.8 percent]). For patients with new versus slow-growing or indolent cancer, lung cancer-specific mortality was significantly higher (9.2 versus 0.9 percent per year). Of the incident cancers, 60 percent of fast-growing progressive cancer and 45 percent of new cancers were stage 1.
"Slow-growing or indolent cancer comprised approximately 25 percent of incident cases, many of which may have been overdiagnosed," the authors write. "To limit overtreatment in these cases, minimally invasive limited resection and nonsurgical treatments should be investigated."
More information: Full Text (subscription or payment may be required)
Journal reference: Annals of Internal Medicine
Copyright © 2012 HealthDay. All rights reserved.
- Asymptomatic often sent for lung cancer screening tests Mar 13, 2012 | not rated yet | 0
- New study looks at growth rates of lung cancers found by CT screening Mar 27, 2012 | not rated yet | 0
- Video-assisted thoracic surgery valuable tool in lung cancer screening May 15, 2012 | not rated yet | 0
- Lymph node dissection is not essential in small screen-detected lung cancers, new research shows Mar 01, 2011 | not rated yet | 0
- CT screening improves lung cancer survival Oct 26, 2006 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.
Cancer 4 hours ago | not rated yet | 0 |
A new study conducted using extensive medical records of over one million Israeli adolescents before military service shows clearly how exposure to the Israeli sun of young, light-skinned children increases substantially ...
Cancer 6 hours ago | not rated yet | 0
A new measure of the heterogeneity – the variety of genetic mutations – of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer. In the May 20 issue ...
Cancer 10 hours ago | not rated yet | 0
Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis—two disorders that are difficult to tell apart. A molecular marker obtained from pancreatic ...
Cancer 10 hours ago | not rated yet | 0
The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in ...
Cancer May 19, 2013 | not rated yet | 0
While the effects of acute stroke have been widely studied, brain damage during the subacute phase of stroke has been a neglected area of research. Now, a new study by the University of South Florida reports that within a ...
55 minutes ago | not rated yet | 0 |
A new report suggests that improved health care and significant reductions in drug costs might be attained by breaking up the age-old relationship between physicians and drug company representatives who promote the newest, ...
58 minutes ago | not rated yet | 0
As high schoolers prepare for final exams, teens nationwide may be tempted to use a "study drug"—a prescription stimulant or amphetamine—to gain an academic edge. But a new University of Michigan poll shows only one in ...
20 minutes ago | not rated yet | 0
Food microbiology laboratories continue to submit false negative results and false positive results on a routine basis. A retrospective study of nearly 40,000 proficiency test results over the past 14 years, presented today ...
44 minutes ago | not rated yet | 0
Posterior fossa subdural hematoma (PFSDH) is a serious and rare condition in newborns, generally occurring after difficult deliveries. But with appropriate treatment, there's an excellent chance of good long-term outcomes ...
47 minutes ago | not rated yet | 0
National guidelines recommend that at-risk women be screened for elevated cholesterol levels to reduce their chances of developing cardiovascular disease. But who is 'at risk?' The results of a study by investigators ...
57 minutes ago | not rated yet | 0