Strict ovarian CA screening adherence called for in high-risk

Strict ovarian CA screening adherence called for in high-risk
For women at higher risk for ovarian and/or fallopian tube cancer, annual screening offers high sensitivity for detection of incident cancers, but few of these cancers are stage I or II, according to research published online Dec. 3 in the Journal of Clinical Oncology.

(HealthDay)—For women at higher risk for ovarian and/or fallopian tube cancer (OC/FTC), annual screening offers high sensitivity for detection of incident cancers, but few of these cancers are stage I or II, according to research published online Dec. 3 in the Journal of Clinical Oncology.

Between 2002 and 2008, Adam N. Rosenthal, M.D., Ph.D., of Barts and the London School of Medicine and Dentistry, and colleagues screened 3,563 women who were estimated to be at a 10 percent or higher of OC/FTC. Women were evaluated using transvaginal ultrasound and serum CA125 screening and followed prospectively.

The researchers found that, at one year after the last annual screening, the sensitivity for detection of incident OC/FTC was 81.3 or 87.5 percent if occult cancers were classified as false negatives or true positives, respectively. For incident screening, the positive and negative predictive values were 25.5 and 99.9 percent, respectively. There were 13 incident screen-detected cases of OC/FTC; only four of these were stage I or II. Women who were not screened in the year before diagnosis were significantly more likely to have stage IIIc disease or higher compared with those who had been screened the year before (85.7 versus 26.1 percent). In prevalent and incident cancer, the median time between detection screen and surgical intervention was 79 days.

"These results in the high-risk population highlight the need for strict adherence to [a] screening schedule," the authors write. "Screening more frequently than annually, with prompt , seems to offer a better chance of early-stage detection."

Several authors disclosed financial ties to medical and diagnostic technology companies.

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

Related Stories

Recommended for you

Study finds new potential melanoma drug target

date May 02, 2015

A new treatment for melanoma could be on the horizon, thanks to a finding by a UNC Lineberger Comprehensive Cancer Center-led team. In the study, which was published online today in the journal Clinical Ca ...

Surgery for terminal cancer patients still common

date May 02, 2015

The number of surgeries performed on terminally ill cancer patients has not dropped in recent years, despite more attention to the importance of less invasive care for these patients to relieve symptoms and ...

Study provides comprehensive look at brain cancer treatments

date May 01, 2015

Led by the Translational Genomics Research Institute (TGen) and UC San Francisco (UCSF), a comprehensive genetic review of treatment strategies for glioblastoma brain tumors was published today in the Oxford University Press ...

How artificial tanning can lead to melanoma

date May 01, 2015

Young women may be up on the latest fashions and trends as they prepare for prom season. But what many don't know is that the tan that looks oh-so-good with their dress may be the first step toward skin cancer.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.