Risk of death up for PE patients with high plasma lactate levels
Adult patients with acute pulmonary embolism with elevated plasma lactate levels are at a high risk of death and adverse outcomes, regardless of whether they also present with shock or hypotension; right-sided ventricular dysfunction; or elevation of troponin I, according to research published online Jan. 9 in the Annals of Emergency Medicine.
(HealthDay)—Adult patients with acute pulmonary embolism (PE) with elevated plasma lactate levels are at a high risk of death and adverse outcomes, regardless of whether they also present with shock or hypotension; right-sided ventricular dysfunction; or elevation of troponin I, according to research published online Jan. 9 in the Annals of Emergency Medicine.
Simone Vanni, M.D., Ph.D., of the Azienda Ospedaliero-Universitaria Careggi in Florence, Italy, and colleagues conducted a prospective study involving 270 patients (mean age, 73 years) with symptomatic, objectively confirmed PE who presented at a single emergency department. Plasma lactate levels were measured to examine their prognostic value.
In total, 6.3 percent of patients died, and of these, 4.4 percent of deaths were attributed to PE; a further 13.7 percent reached the composite end point of all-cause death and clinical deterioration. The researchers found that mortality was significantly higher for those with a lactate level ≥2 mmol/L compared with those with a lower level (17.3 versus 1.6 percent). Independent of shock or hypotension, right-sided ventricular dysfunction, or elevation of troponin I values, elevated plasma lactate levels correlated with a significantly increased risk of all-cause death (hazard ratio, 11.67) and the composite end point (hazard ratio, 8.14).
"Patients with acute pulmonary embolism and high plasma lactate levels should undergo strict medical surveillance and monitoring," Vanni said in a statement. "A multicenter prospective study is now warranted to confirm or to extend our knowledge about the prognostic value of plasma lactate levels in these patients."
More information: Abstract
Full Text (subscription or payment may be required)
Journal reference: Annals of Emergency Medicine
Copyright © 2013 HealthDay. All rights reserved.
- Unsuspected PE seldom linked to death in cancer patients Oct 09, 2012 | not rated yet | 0
- Glucose levels at admission predict death in pneumonia May 30, 2012 | not rated yet | 0
- Unsuspected PE does not up mortality risk in cancer patients Aug 06, 2012 | not rated yet | 0
- Risk of pulmonary embolism greatest during first week following total joint replacement Feb 07, 2012 | not rated yet | 0
- Early surgery ups outcomes in infective endocarditis Jun 28, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
Diseases, Conditions, Syndromes 9 hours ago | not rated yet | 0
There are significant cost and risk factors associated with two procedures commonly used to diagnose or treat gastrointestinal problems, according to research presented at Digestive Disease Week (DDW).
Diseases, Conditions, Syndromes 21 hours ago | not rated yet | 0
Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, Mayo Clinic research shows. The findings were being presented at the Digestive Disease ...
Diseases, Conditions, Syndromes 21 hours ago | not rated yet | 0 |
A new case of the deadly coronavirus has been detected in Saudi Arabia where 15 people have already died after contracting it, the health ministry announced on Saturday on its Internet website.
Diseases, Conditions, Syndromes May 18, 2013 | not rated yet | 0
(HealthDay)—Few randomized clinical trials have been done to assess clinical prediction rules for patients with lower back pain, and the trials that have been done are of low quality and do not provide ...
Diseases, Conditions, Syndromes May 17, 2013 | not rated yet | 0 |
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
9 hours ago | not rated yet | 0 |
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
10 hours ago | 5 / 5 (2) | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
10 hours ago | 4.8 / 5 (4) | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
9 hours ago | 5 / 5 (2) | 0 |
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
14 hours ago | not rated yet | 0
Patients with treatment-resistant major depression saw dramatic improvement in their illness after treatment with ketamine, an anesthetic, according to the largest ketamine clinical trial to-date led by researchers from the ...
21 hours ago | 4.8 / 5 (5) | 1 |