Risk of death up for PE patients with high plasma lactate levels

Risk of death up for PE patients with high plasma lactate levels
Adult patients with acute pulmonary embolism with elevated plasma lactate levels are at a high risk of death and adverse outcomes, regardless of whether they also present with shock or hypotension; right-sided ventricular dysfunction; or elevation of troponin I, according to research published online Jan. 9 in the Annals of Emergency Medicine.

(HealthDay)—Adult patients with acute pulmonary embolism (PE) with elevated plasma lactate levels are at a high risk of death and adverse outcomes, regardless of whether they also present with shock or hypotension; right-sided ventricular dysfunction; or elevation of troponin I, according to research published online Jan. 9 in the Annals of Emergency Medicine.

Simone Vanni, M.D., Ph.D., of the Azienda Ospedaliero-Universitaria Careggi in Florence, Italy, and colleagues conducted a prospective study involving 270 patients (mean age, 73 years) with symptomatic, objectively confirmed PE who presented at a single emergency department. Plasma lactate levels were measured to examine their .

In total, 6.3 percent of patients died, and of these, 4.4 percent of deaths were attributed to PE; a further 13.7 percent reached the composite end point of all-cause death and clinical deterioration. The researchers found that mortality was significantly higher for those with a lactate level ≥2 mmol/L compared with those with a lower level (17.3 versus 1.6 percent). Independent of shock or hypotension, right-sided ventricular dysfunction, or elevation of troponin I values, elevated plasma lactate levels correlated with a significantly increased risk of all-cause death (hazard ratio, 11.67) and the composite end point (hazard ratio, 8.14).

"Patients with acute pulmonary embolism and high plasma lactate levels should undergo strict medical surveillance and monitoring," Vanni said in a statement. "A multicenter prospective study is now warranted to confirm or to extend our knowledge about the prognostic value of plasma levels in these patients."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Unsuspected PE seldom linked to death in cancer patients

Oct 09, 2012

(HealthDay)—Unsuspected pulmonary embolism (UPE) is not associated with an increased risk of death in cancer patients when compared to patients without pulmonary embolism (PE), according to research published ...

Glucose levels at admission predict death in pneumonia

May 30, 2012

(HealthDay) -- For patients with community-acquired pneumonia without preexisting diabetes, serum glucose levels at admission are predictive of death at 28 and 90 days, according to a study published online ...

Early surgery ups outcomes in infective endocarditis

Jun 28, 2012

(HealthDay) -- For patients with infective endocarditis and large vegetations, early surgery reduces death from any cause and embolic events, compared with conventional treatment, according to a study published ...

Recommended for you

Kidney-brain connection may help drive chronic kidney disease

12 hours ago

In addition to affecting blood pressure, high-salt intake can promote kidney function decline in patients with chronic kidney disease. A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (J ...

Flu's grip on U.S. starting to weaken: CDC

13 hours ago

(HealthDay)—After a rough start to the flu season, the number of infections seems to have peaked and is even starting to decline in many parts of the nation, federal health officials reported Thursday.

Litchi fruit suspected in mystery illness in India

13 hours ago

A mysterious and sometimes fatal brain disease that has afflicted children in northeastern India for years could be linked to a toxic substance in litchi fruits, US researchers said Thursday.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.