Depressive symptoms tied to doubled risk for Crohn's

Depressive symptoms tied to doubled risk  for crohn's
Depressive symptoms are associated with a two-fold increase in risk of Crohn's disease but not ulcerative colitis, according to research published in the January issue of Clinical Gastroenterology and Hepatology.

(HealthDay)—Depressive symptoms are associated with a two-fold increase in risk of Crohn's disease (CD) but not ulcerative colitis (UC), according to research published in the January issue of Clinical Gastroenterology and Hepatology.

Ashwin N. Ananthakrishnan, M.B.B.S., M.P.H., of Massachusetts General Hospital and Harvard Medical School in Boston, and colleagues prospectively collected data from 152,461 women who participated in either the Nurses' I or II. The authors sought to determine whether there is a link between and the incidence of CD and UC.

A total of 170 cases of CD and 203 cases of UC were reported while following this patient population. The researchers found that women with recent depressive symptoms, defined as within the past four years, were 2.39-fold more likely to be diagnosed with CD. Women with depressive symptoms at baseline were 1.62-fold (95 percent confidence interval, 0.94 to 2.77) more likely to have CD. However, no association was found between either baseline or recent depressive symptoms and an increased risk of UC.

"We observed that depressive symptoms are associated with a two-fold increase in risk of CD but not UC. Although both recent (within four years) and remote (baseline) assessments of depression appear to influence , the association with recent depressive symptoms appeared more prominent," the authors write. "Our findings support the potential importance of a biopsychosocial model in the pathogenesis of CD and suggest the need for further studies on the effect of depression and stress on and regulation."

Two authors disclosed to pharmaceutical and health policy companies.

More information: Abstract
Full Text

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

How children categorize living things

7 hours ago

How would a child respond to this question? Would his or her list be full of relatives, animals from movies and books, or perhaps neighborhood pets? Would the poppies blooming on the front steps make the list or the oak tree ...

Preschoolers can reflect on what they don't know

7 hours ago

Contrary to previous assumptions, researchers find that preschoolers are able to gauge the strength of their memories and make decisions based on their self-assessments. The study findings are published in ...

User comments