Depressive symptoms tied to doubled risk for Crohn's

January 16, 2013
Depressive symptoms tied to doubled risk  for crohn's
Depressive symptoms are associated with a two-fold increase in risk of Crohn's disease but not ulcerative colitis, according to research published in the January issue of Clinical Gastroenterology and Hepatology.

(HealthDay)—Depressive symptoms are associated with a two-fold increase in risk of Crohn's disease (CD) but not ulcerative colitis (UC), according to research published in the January issue of Clinical Gastroenterology and Hepatology.

Ashwin N. Ananthakrishnan, M.B.B.S., M.P.H., of Massachusetts General Hospital and Harvard Medical School in Boston, and colleagues prospectively collected data from 152,461 women who participated in either the Nurses' I or II. The authors sought to determine whether there is a link between and the incidence of CD and UC.

A total of 170 cases of CD and 203 cases of UC were reported while following this patient population. The researchers found that women with recent depressive symptoms, defined as within the past four years, were 2.39-fold more likely to be diagnosed with CD. Women with depressive symptoms at baseline were 1.62-fold (95 percent confidence interval, 0.94 to 2.77) more likely to have CD. However, no association was found between either baseline or recent depressive symptoms and an increased risk of UC.

"We observed that depressive symptoms are associated with a two-fold increase in risk of CD but not UC. Although both recent (within four years) and remote (baseline) assessments of depression appear to influence , the association with recent depressive symptoms appeared more prominent," the authors write. "Our findings support the potential importance of a biopsychosocial model in the pathogenesis of CD and suggest the need for further studies on the effect of depression and stress on and regulation."

Two authors disclosed to pharmaceutical and health policy companies.

Explore further: Depressive symptoms and impaired physical function are frequent and long-lasting after ALI

More information: Abstract
Full Text

Related Stories

Low insulin secretion tied to depressive symptoms in women

December 29, 2012

(HealthDay)—Middle-aged women with insulin secretion levels in the lowest quintile appear to have more than twice the risk of developing new-onset depressive symptoms compared with those with higher insulin secretion levels, ...

Recommended for you

Is neuroticism fueled by overthinking?

August 27, 2015

Isaac Newton was a classic neurotic. He was a brooder and a worrier, prone to dwelling on the scientific problems before him as well as his childhood sins. But Newton also had creative breakthroughs—thoughts on physics ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.