Depressive symptoms tied to doubled risk for Crohn's

Depressive symptoms tied to doubled risk  for crohn's
Depressive symptoms are associated with a two-fold increase in risk of Crohn's disease but not ulcerative colitis, according to research published in the January issue of Clinical Gastroenterology and Hepatology.

(HealthDay)—Depressive symptoms are associated with a two-fold increase in risk of Crohn's disease (CD) but not ulcerative colitis (UC), according to research published in the January issue of Clinical Gastroenterology and Hepatology.

Ashwin N. Ananthakrishnan, M.B.B.S., M.P.H., of Massachusetts General Hospital and Harvard Medical School in Boston, and colleagues prospectively collected data from 152,461 women who participated in either the Nurses' I or II. The authors sought to determine whether there is a link between and the incidence of CD and UC.

A total of 170 cases of CD and 203 cases of UC were reported while following this patient population. The researchers found that women with recent depressive symptoms, defined as within the past four years, were 2.39-fold more likely to be diagnosed with CD. Women with depressive symptoms at baseline were 1.62-fold (95 percent confidence interval, 0.94 to 2.77) more likely to have CD. However, no association was found between either baseline or recent depressive symptoms and an increased risk of UC.

"We observed that depressive symptoms are associated with a two-fold increase in risk of CD but not UC. Although both recent (within four years) and remote (baseline) assessments of depression appear to influence , the association with recent depressive symptoms appeared more prominent," the authors write. "Our findings support the potential importance of a biopsychosocial model in the pathogenesis of CD and suggest the need for further studies on the effect of depression and stress on and regulation."

Two authors disclosed to pharmaceutical and health policy companies.

More information: Abstract
Full Text

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Research shows seven-year-olds can think strategically

2 hours ago

(Medical Xpress)—A study by Melissa Koenig of the University of Minnesota and colleagues shows that by the time they reach the age of seven, children can think strategically, in an adult manner. The researchers ...

Discovery hints at why stress is more devastating for some

6 hours ago

Some people take stress in stride; others are done in by it. New research at Rockefeller University has identified the molecular mechanisms of this so-called stress gap in mice with very similar genetic backgrounds—a ...

User comments