Single, fractional dose of polio vaccine induces priming

Single, fractional dose of polio vaccine induces priming
Priming immune responses are induced in most infants after vaccination with a single dose of inactivated poliovirus vaccine, according to a study published in the Jan. 31 issue of the New England Journal of Medicine.

(HealthDay)—Priming immune responses are induced in most infants after vaccination with a single dose of inactivated poliovirus vaccine (IPV), according to a study published in the Jan. 31 issue of the New England Journal of Medicine.

Sonia Resik, M.D., Ph.D., from the Pedro Kouri Institute in , and colleagues assessed the extent of priming immune responses after the administration of IPV in a cohort of 310 Cuban infants who were randomized to receive a fractional dose of IPV (one-fifth of a full dose) or a full dose administered at the ages of 4 and 8 months.

The researchers found that seroconversion to poliovirus types 1, 2, and 3 occurred in 16.6, 47.1, and 14.7 percent of infants, respectively, in the group receiving the first fractional dose of IPV, compared with 46.6, 62.8, and 32.0 percent, respectively, of those receiving the first full IPV dose (P < 0.008 for all comparisons). In the fractional dose group, a priming occurred in 90.8, 94.0, and 89.6 percent of infants, respectively, as compared with 97.6, 98.3, and 98.1 percent, respectively, of those receiving the full dose (P = 0.01 for the comparison with poliovirus type 3). Cumulative two-dose seroconversion occurred in 93.6, 98.1, and 93.0 percent of infants, respectively, after administration of the second dose of IPV in the group receiving fractional doses, compared with 100.0, 100.0, and 99.4 percent, respectively, in those receiving the full dose (P < 0.006 for types 1 and 3).

"Vaccinating infants with a single fractional dose of IPV can induce priming and seroconversion in more than 90 percent of immunized infants," the authors write.

More information: Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Third MMR vaccine dose can curtail mumps outbreak

Nov 05, 2012

(HealthDay)—Administering a third dose of the measles-mumps-rubella (MMR) vaccine reduced the village-wide attack rate by about 75 percent in a community experiencing a large mumps outbreak despite a high ...

Recommended for you

Two expats die of MERS in Saudi commercial hub

Apr 20, 2014

Two foreigners died of MERS in the Saudi city of Jeddah, the health ministry said Saturday, as fears rise over the spreading respiratory virus in the kingdom's commercial hub.

UAE reports 12 new cases of MERS

Apr 20, 2014

Health authorities in the United Arab Emirates have announced 12 new cases of infection by the MERS coronavirus, but insisted the patients would be cured within two weeks.

Filipino tests negative for Middle East virus

Apr 19, 2014

A Filipino nurse who tested positive for the Middle East virus has been found free of infection in a subsequent examination after he returned home, Philippine health officials said Saturday.

User comments