Single, fractional dose of polio vaccine induces priming

January 31, 2013
Single, fractional dose of polio vaccine induces priming
Priming immune responses are induced in most infants after vaccination with a single dose of inactivated poliovirus vaccine, according to a study published in the Jan. 31 issue of the New England Journal of Medicine.

(HealthDay)—Priming immune responses are induced in most infants after vaccination with a single dose of inactivated poliovirus vaccine (IPV), according to a study published in the Jan. 31 issue of the New England Journal of Medicine.

Sonia Resik, M.D., Ph.D., from the Pedro Kouri Institute in , and colleagues assessed the extent of priming immune responses after the administration of IPV in a cohort of 310 Cuban infants who were randomized to receive a fractional dose of IPV (one-fifth of a full dose) or a full dose administered at the ages of 4 and 8 months.

The researchers found that seroconversion to poliovirus types 1, 2, and 3 occurred in 16.6, 47.1, and 14.7 percent of infants, respectively, in the group receiving the first fractional dose of IPV, compared with 46.6, 62.8, and 32.0 percent, respectively, of those receiving the first full IPV dose (P < 0.008 for all comparisons). In the fractional dose group, a priming occurred in 90.8, 94.0, and 89.6 percent of infants, respectively, as compared with 97.6, 98.3, and 98.1 percent, respectively, of those receiving the full dose (P = 0.01 for the comparison with poliovirus type 3). Cumulative two-dose seroconversion occurred in 93.6, 98.1, and 93.0 percent of infants, respectively, after administration of the second dose of IPV in the group receiving fractional doses, compared with 100.0, 100.0, and 99.4 percent, respectively, in those receiving the full dose (P < 0.006 for types 1 and 3).

"Vaccinating infants with a single fractional dose of IPV can induce priming and seroconversion in more than 90 percent of immunized infants," the authors write.

Explore further: Extended infant antiretroviral prophylaxis reduces HIV risk during breastfeeding

More information: Full Text (subscription or payment may be required)

Related Stories

Third MMR vaccine dose can curtail mumps outbreak

November 5, 2012

(HealthDay)—Administering a third dose of the measles-mumps-rubella (MMR) vaccine reduced the village-wide attack rate by about 75 percent in a community experiencing a large mumps outbreak despite a high rate of previous ...

High-dose flu vaccine better protects HIV-infected adults

January 4, 2013

(HealthDay)—HIV-infected adults achieve higher rates of seroprotection when immunized with a high-dose of the influenza trivalent vaccine compared to the standard dose, according to a study published in the Jan. 1 issue ...

Recommended for you

Zika virus may persist in the vagina days after infection

August 25, 2016

The Zika virus reproduces in the vaginal tissue of pregnant mice several days after infection, according to a study by Yale researchers. From the genitals, the virus spreads and infects the fetal brain, impairing fetal development. ...

In sub-Saharan Africa, cancer can be an infectious disease

August 26, 2016

In 1963, Irish surgeon Denis Parson Burkitt airmailed samples of an unusual jaw tumor found in Ugandan children to his colleague, Anthony Epstein, at Middlesex Hospital in London. Epstein, an expert in chicken viruses and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.