Gum disease found to worsen infection in animal model of AIDS
Texas Biomed scientists in San Antonio have found that moderate gum disease in an animal model exposed to an AIDS- like virus had more viral variants causing infection and greater inflammation. Both of these features have potential negative implications in long term disease progression, including other kinds of infections, the researchers say in a new report.
The public health message from the study is that even mild inflammation in the mouth needs to be controlled because it can lead to more serious consequences, said Luis Giavedoni, Ph. D, a Texas Biomed virologist and first author of the study.
"This is important because moderate gum disease is present in more than 50 percent of the world population. It is known that severe gum disease leads to generalized inflammation and a number of other health complications, but the conditions that we created were moderate and they were mainly localized in the mouth," he added.
"After infection with the simian AIDS virus, the generalized acute inflammation induced by the virus was exacerbated in the animals with gingivitis, indicating that even mild localized inflammation can lead to a more severe systemic inflammation," he added.
The study, funded by the National Institutes of Health (NIH) and conducted at Texas Biomed's Southwest National Primate Research Center (SNPRC), appears in the February 2013 issue of the Journal of Virology. Collaborators included scientists at the Dental School at UT Health Science Center San Antonio and at Seattle Biomed in Washington State.
Giavedoni and his colleagues studied whether inflammation of the mouth would increase the susceptibility of the monkeys to becoming infected with the monkey AIDS virus. This was based on epidemiological evidence that shows that infection and inflammation of the genital mucosa increases the chances of becoming infected with HIV by the sexual route.
The scientists induced moderate gum inflammation in a group of monkeys, while a second group without gum inflammation served as a control. After exposing both groups of macaques to infectious SIV, a monkey virus similar to AIDS, in the mouth they did not observe differences in the rate of infection, indicating the moderate gum disease did not increase the chances of getting infected with the AIDS virus.
"However, we did observe that the animals that had gum inflammation and got infected had more viral variants causing infection and they also showed augmented systemic inflammation after infection; both of these findings may negatively affect the progression of the viral infection." Giavedoni said.
Journal reference: Journal of Virology
Provided by Texas Biomedical Research Institute
- Evidence that new biomimetic controlled-release capsules may help in gum disease Aug 20, 2012 | not rated yet | 0
- AIDS resistance secret may be in blood Feb 12, 2007 | not rated yet | 0
- Little-known mouth fluid may lead to test for gum disease May 26, 2010 | not rated yet | 0
- Sexually transmitted co-infections increase HIV risk: study Jun 20, 2011 | not rated yet | 0
- Could probiotics help HIV patients? Jan 16, 2013 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
(HealthDay)—For HIV-infected individuals with recurrent Clostridium difficile infection, fecal microbiota therapy is feasible, according to a letter published in the May 21 issue of the Annals of Intern ...
HIV & AIDS 13 hours ago | not rated yet | 0
Canadian health authorities lifted Wednesday what was effectively a ban on gay men giving blood, announcing new rules making men who have not had sex with men in the past five years eligible.
HIV & AIDS 15 hours ago | not rated yet | 1
Top AIDS scientists were optimistic Wednesday of finding a cure for the disease that has claimed 30 million lives—but said it might not work for all people.
HIV & AIDS 18 hours ago | not rated yet | 0
The integration of mental health interventions into HIV prevention and treatment platforms can reduce the opportunity costs of care and improve treatment outcomes, argues a new Policy Forum article published in this week's ...
HIV & AIDS May 21, 2013 | not rated yet | 0
(Medical Xpress)—Researchers at the University of Virginia School of Medicine have identified a promising target for treating glioblastoma, one that appears to avoid many of the obstacles that typically frustrate efforts ...
29 minutes ago | not rated yet | 0 |
(Medical Xpress)—The first symptoms of major depression may be behavioral, but the common mental illness is based in biology—and not limited to the brain.
24 minutes ago | not rated yet | 0 |
(Medical Xpress)—Scientists at Emory Vaccine Center have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.
18 minutes ago | not rated yet | 0 |
Human breastmilk responds quickly to protect the child when there is an infection in mothers or babies, according to new international research led by The University of Western Australia.
30 minutes ago | not rated yet | 0
More than half of patients diagnosed with Non-Hodgkin Lymphoma (NHL) are now surviving the disease thanks to improved diagnosis and treatment, according to a new report1 from Cancer Research UK.
4 minutes ago | not rated yet | 0
To coincide with the broadcast of Jabbed: Love, Fear and Vaccines (SBS ONE, Sunday 26 May at 8.30pm) the first ever national survey on Australian attitudes to vaccination reveals surprising statistics including half of Australians ...
11 minutes ago | not rated yet | 0