Human breast milk microbiome changes over time

Human breast milk microbiome changes over time
The microbiome of breast milk is influenced by many factors, including maternal weight and how the baby was delivered, according to research published in the American Journal of Clinical Nutrition.

(HealthDay)—The microbiome of breast milk is influenced by many factors, including maternal weight and how the baby was delivered, according to research published in the American Journal of Clinical Nutrition.

Raul Cabrera-Rubio, M.D., of the University of Valencia in Spain, and colleagues used pyrosequencing and quantitative methods to characterize the microbial community of the of 18 mothers at three different time points and identify pre- and postnatal factors that can influence the breast milk microbiome.

The researchers found that colostrum contained primarily Weisella, Leuconostoc, Staphylococcus, Streptococcus, and Lactococcus, while samples collected at one and six months contained more Veillonella, Leptotrichia, and Prevotella species. displayed a different and less diverse bacterial community. Additionally, the microbiome differed according to whether the baby was delivered vaginally or via non-elective or elective cesarean section, suggesting a role for physiologic stress and/or hormonal signals in the transmission of bacteria into breast milk.

"Prenatal and postnatal microbial exposures have profound effects on the microbial colonization of the intestine and maturation of the nave immune system," the authors write. "Given that the bacteria present in breast milk are among the very first microbes that enter the human body and given the vital role of bacteria in the infant's physiology and development of the immune system, our data emphasize the necessity to understand the biological role that the breast milk microbiome could potentially play for human health."

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