Can we all just get along? Immunological memory learns tolerance
In this image from the UConn Health Center immunology researchers’ study, the T cells are depicted in green, while the red indicates dendritic cells, or cells that deliver antigens. Credit: Lefrançois Lab
(Medical Xpress)—Immunology researchers at the University of Connecticut Health Center are learning more about memory T cells, which are cells that fight infection from a previously encountered antigen.
"This work shows that under normal circumstances, memory T cells ignore self-antigens, thereby prohibiting autoimmunity," says Leo Lefrançois, Department of Immunology chair, whose laboratory developed a genetically modified mouse model that made the research possible. "However, when inflammation is introduced the memory cells can respond, helping to explain why infections can trigger autoimmune diseases."
Memory T cells normally exist to protect from re-infection. But memory T cells also can cause autoimmune disease when they cross-react with self-antigens, sometimes triggered by infection.
An antigen is a substance normally foreign to the body that evokes an immune response and is bound by T cells. Autoimmunity can occur when T cells bind self-antigens. Co-authors include Evan Jellison, assistant professor of immunology, Lynn Puddington, associate professor of immunology and medicine, former UConn Health Center postdoctoral fellow Michael Turner, and research assistants Elizabeth Lingenheld and Li Zhu. Their work is published in the Dec. 26 issue of the Proceedings of the National Academy of Sciences.
"These results have implications for relapsing remitting forms of autoimmune disease as well as for cancer therapy where memory T cells might ignore tumor antigens but could potentially be triggered to attack the tumor," Jellison says.
More information: www.ncbi.nlm.nih.g… med/23236165
Journal reference: Proceedings of the National Academy of Sciences
Provided by University of Connecticut
- Research describes advantages of new vaccine adjuvant Dec 12, 2011 | not rated yet | 0
- Early activation of immune response could lead to better vaccines Aug 30, 2012 | not rated yet | 0
- Researcher decodes the language of memory cells in Science article Jan 22, 2009 | not rated yet | 0
- Rare B cells regulate immune responses, may offer novel treatment for autoimmune diseases Oct 14, 2012 | not rated yet | 0
- The immune system has protective memory cells, researchers discover Nov 28, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
gravity is std. therefore can we rate a 'mass at height' by watts?
3 hours ago For example.... wind turbines are primarily listed by their wattage (1.5MW etc.) Presumably their output is varied according to rotational speed, so...
Calculating on-axis elements of a solenoid
15 hours ago I wanted to mention that this solenoid has many winds over many layers. The thickness of the windings is 2.4 inches coming off of the engineering...
latitude & longitude & air pressure
17 hours ago Hi there, I have a peculiar question. Imagine that you are in a earth position, obtained by google, that gives you the latitude and longitude....
Differences of Classical Mechanics when learned with Calc vs algebra?
20 hours ago what are the differences? Every example I find usually has a derivative or integral or some kind of calculus defined concept that seems to make it...
what is the distance traveled
May 22, 2013 A rough sketch of experiment. Image: http://i43.tinypic.com/14t4sk5.png the red dots represent a side view of path traveled, F is downward force...
Image of a Convex Lens Cut in Half Horizontally
May 22, 2013 Hello everyone, A friend of mine came up with this question in class and I really do not have a good answer. Suppose you have a convex lens...
- More from Physics Forums - Classical Physics
More news stories
(Medical Xpress)—Scientists at Emory Vaccine Center have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.
Immunology 5 hours ago | 5 / 5 (1) | 0 |
Human breastmilk responds quickly to protect the child when there is an infection in mothers or babies, according to new international research led by The University of Western Australia.
Immunology 5 hours ago | 5 / 5 (1) | 0
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.
Immunology May 20, 2013 | 4.8 / 5 (25) | 8 |
(Medical Xpress)—Scientists at King's College London have discovered that Vitamin D has the potential to significantly reduce the symptoms of asthma. The study, led by Professor Catherine Hawrylowicz from ...
Immunology May 20, 2013 | 5 / 5 (1) | 0 |
A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose ...
1 hour ago | 5 / 5 (2) | 0 |
Gaucher disease causes debilitating and sometimes fatal neurodegeneration in early childhood. Recent studies have uncovered a link between the mutations responsible for Gaucher disease and an increased risk ...
54 minutes ago | not rated yet | 0 |
Spanish researchers have discovered that the daily clearance of neutrophils from the body stimulates the release of hematopoietic stem cells from the bone marrow into the bloodstream, according to a report published today ...
1 hour ago | not rated yet | 0
Treating pediatric leukemia patients with a liposomal formulation of anthracycline-based chemotherapy at a more intense-than-standard dose during initial treatment may result in high survival rates without causing any added ...
58 minutes ago | not rated yet | 0
Family caregivers of older adults with dementia are less stressed and their moods are improved on days when dementia patients receive adult day services (ADS), according to Penn State researchers.
57 minutes ago | not rated yet | 0