Tracing the impact of amyloid beta in mild cognitive impairment

January 15, 2013
It should just say that in two woman of the same age with similar memory complaints, one (top images) has no evidence of amyloid plaques while the other (bottom row) has extensive amyloid plaques (red and yellow areas) in the cortex around the edge of the brain indicating the presence of Alzheimer's disease. Credit: Christopher Rowe and Victor Villemagne

The amount of amyloid β (Aβ) in the brains of people with mild cognitive impairment (MCI) is contributing to early memory loss, and increases with severity of symptoms, finds a study in BioMed Central's open access journal Alzheimer's Research & Therapy. The non-invasive study which used 18F-florbetaben to find Aβ plaques in brain scans to also show that in MCI the affect of Aβ on memory loss is independent of other aspects of mental decline.

Positron emission tomography (PET) has previously relied on carbon-11 labeling of Aβ, however this study uses 18F-florbetaben which can be used for longer and allow more patients to be scanned at lower cost. A higher than normal amount of Aβ was found in half of the PET scans of people with MCI. Interestingly there was a strong association between Aβ and , but not with other features of neurodegeneration, such as hippocampal atrophy or the white matter hyperintensities frequently seen on MRI later in the development of Alzheimer's disease.

Prof Christopher Rowe, from Austin Health, Australia and the University of Melbourne, who led the study explained why it is important, "MCI is thought to affect between one in five and one in ten of all adults over the age of 65, and, although some of these will go on to develop dementia within a few years, the majority can lead a relatively normal life. Detection of Aβ plaques in MCI indicates early Alzheimer's disease, while a negative scan eliminates this possibility. Consequently a negative scan is very reassuring while a positive scan can lead to earlier and more appropriate medical and social management."

Explore further: New research supports upcoming Alzheimer's disease guidelines

More information: 18F-florbetaben Abeta imaging in mild cognitive impairment Kevin Ong, Victor L Villemagne, Alex Bahar-Fuchs, Fiona Lamb, Gaël Chételat, Parnesh Raniga, Rachel S Mulligan, Olivier Salvado, Barbara Putz, Katrin Roth, Colin L Masters, Cornelia B Reininger and Christopher C Rowe, Alzheimer's Research & Therapy (in press)

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