Tracing the impact of amyloid beta in mild cognitive impairment
It should just say that in two woman of the same age with similar memory complaints, one (top images) has no evidence of amyloid plaques while the other (bottom row) has extensive amyloid plaques (red and yellow areas) in the cortex around the edge of the brain indicating the presence of Alzheimer's disease. Credit: Christopher Rowe and Victor Villemagne
The amount of amyloid β (Aβ) in the brains of people with mild cognitive impairment (MCI) is contributing to early memory loss, and increases with severity of symptoms, finds a study in BioMed Central's open access journal Alzheimer's Research & Therapy. The non-invasive study which used 18F-florbetaben to find Aβ plaques in brain scans to also show that in MCI the affect of Aβ on memory loss is independent of other aspects of mental decline.
Positron emission tomography (PET) has previously relied on carbon-11 labeling of Aβ, however this study uses 18F-florbetaben which can be used for longer and allow more patients to be scanned at lower cost. A higher than normal amount of Aβ was found in half of the PET scans of people with MCI. Interestingly there was a strong association between Aβ and memory loss, but not with other features of neurodegeneration, such as hippocampal atrophy or the white matter hyperintensities frequently seen on MRI later in the development of Alzheimer's disease.
Prof Christopher Rowe, from Austin Health, Australia and the University of Melbourne, who led the study explained why it is important, "MCI is thought to affect between one in five and one in ten of all adults over the age of 65, and, although some of these will go on to develop dementia within a few years, the majority can lead a relatively normal life. Detection of Aβ plaques in MCI indicates early Alzheimer's disease, while a negative scan eliminates this possibility. Consequently a negative scan is very reassuring while a positive scan can lead to earlier and more appropriate medical and social management."
More information: 18F-florbetaben Abeta imaging in mild cognitive impairment Kevin Ong, Victor L Villemagne, Alex Bahar-Fuchs, Fiona Lamb, Gaël Chételat, Parnesh Raniga, Rachel S Mulligan, Olivier Salvado, Barbara Putz, Katrin Roth, Colin L Masters, Cornelia B Reininger and Christopher C Rowe, Alzheimer's Research & Therapy (in press)
Journal reference: Alzheimer\'s Research & Therapy
Provided by BioMed Central
- New research supports upcoming Alzheimer's disease guidelines Aug 01, 2011 | not rated yet | 0
- Study shows antibody therapy clears Alzheimer's plaques in mice Dec 05, 2012 | not rated yet | 0
- Neurons die in Alzheimer's because of faulty cell cycle control before plaques and tangles appear Dec 17, 2012 | not rated yet | 0
- Immune cells of the brain renew hopes for curing Alzheimer's disease Nov 30, 2012 | not rated yet | 0
- Scientists reverse Alzheimer's-like memory loss in animal models by blocking EGFR signaling Sep 24, 2012 | not rated yet | 0
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Relating physics forces and entropy
5 hours ago Consider proton and electron are seperated in space at some finite distance.Now suppose they released then the decrease in potential energy equals...
Force Between Two Concentric Solenoids
8 hours ago Imagine a finite length solenoid with outer radius R1 and inner radius R2. This solenoid has a time-varying current going though it. This solenoid is...
Synchrotron, question about insertion devices and electron velocity
8 hours ago When an electron enters an insertion device (wiggler and undulator) from the storage ring in a synchrotron the tangential velocity is equal to the...
Equating differentials => equating coefficients
10 hours ago Hi all, In thermodynamics one often has equations like A dx + B dy = ∂f/∂x dx + ∂f/∂y dy From which follows A = ∂f/∂x B = ∂f/∂y
The idea behind a reverse shock
16 hours ago So in a supernova explosion for example (5th slide) http://www.astro.princeton.edu/~burrows/classes/541/blastwavesChisari.pdf Ambient medium is...
Guass's Law for a charge distribution
16 hours ago First, this is not a homework question, just something I've been confused about for some time. I understand how to use Guass's law in many ways but...
- More from Physics Forums - Classical Physics
More news stories
In the search for medication against Alzheimer's disease, scientists have focused – among other factors – on drugs that can break down Amyloid beta (A-beta). After all, it is the accumulation of A-beta that causes the ...
Alzheimer's disease & dementia May 24, 2013 | 5 / 5 (1) | 0
(Medical Xpress)—The way Alzheimer's disease is portrayed by advocacy groups and the media is having undue influence on the euthanasia debate, according to a Deakin University nursing ethics professor.
Alzheimer's disease & dementia May 24, 2013 | 5 / 5 (1) | 2
Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important benefit? The common baking spice might hold the key to delaying the onset of –– or warding off ...
Alzheimer's disease & dementia May 23, 2013 | 5 / 5 (6) | 0 |
An anti-cancer drug reverses memory deficits in an Alzheimer's disease mouse model, University of Pittsburgh Graduate School of Public Health researchers confirm in the journal Science.
Alzheimer's disease & dementia May 23, 2013 | 5 / 5 (1) | 0 |
Teams of highly respected Alzheimer's researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal Science.
Alzheimer's disease & dementia May 23, 2013 | 3.7 / 5 (3) | 3 |
22 hours ago | 5 / 5 (6) | 5
22 hours ago | 5 / 5 (1) | 1
14 hours ago | not rated yet | 1
May 20, 2013 | 4.8 / 5 (31) | 9 |
May 22, 2013 | 4.3 / 5 (6) | 6 |
May 20, 2013 | 4.9 / 5 (7) | 5 |