Induction of adult cortical neurogenesis by an antidepressant

January 4, 2013

The production of new neurons in the adult normal cortex in response to the antidepressant, fluoxetine, is reported in a study published online this week in Neuropsychopharmacology.

The research team, which is based at the Institute for Comprehensive Medical Science, Fujita Health University, Aichi, has previously demonstrated that exist at the surface of the adult cortex, and, moreover, that ischemia enhances the generation of new from these neural progenitor cells. These cells were accordingly named "Layer 1 Inhibitory Neuron Progenitor cells" (L1-INP). However, until now it was not known whether L1-INP-related neurogenesis could be induced in the normal adult cortex.

Tsuyoshi Miyakawa, Koji Ohira, and their colleagues employed fluoxetine, a , and one of the most widely used antidepressants, to stimulate the production of new neurons from L1-INP cells. A large percentage of these newly generated neurons were inhibitory GABAergic interneurons, and their generation coincided with a reduction in apoptotic cell death following ischemia. This finding highlights the potential neuroprotective response induced by this antidepressant drug. It also lends further support to the postulation that induction of adult neurogenesis in cortex is a relevant prevention/treatment option for and psychiatric disorders.

Explore further: Disinhibition plus instruction improve brain plasticity

Related Stories

Disinhibition plus instruction improve brain plasticity

April 12, 2011

(PhysOrg.com) -- The healthy brain has balance of excitatory and inhibitory signals that stimulate activity but also keep it under control. Some brain diseases, like autism and Down's syndrome, have too much inhibition, which ...

Recommended for you

Fast and slow—learning how the brain controls movement

May 4, 2016

What if you couldn't move faster even when you wanted to? Researchers thought that the part of the brain that determines how fast we perform voluntary movements, such as walking across a room or playing a melody on the piano, ...

Aggregated protein in nerve cells can cause ALS

May 4, 2016

Persons with the serious disorder ALS, can have a genetic mutation that causes the protein SOD1 to aggregate in motor neurons in the brain and spinal cord. Researchers at Umeå University have discovered that, when injected ...

Adult brain prunes branched connections of new neurons

May 2, 2016

When tweaking its architecture, the adult brain works like a sculptor—starting with more than it needs so it can carve away the excess to achieve the perfect design. That's the conclusion of a new study that tracked developing ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.