Induction of adult cortical neurogenesis by an antidepressant

January 4, 2013

The production of new neurons in the adult normal cortex in response to the antidepressant, fluoxetine, is reported in a study published online this week in Neuropsychopharmacology.

The research team, which is based at the Institute for Comprehensive Medical Science, Fujita Health University, Aichi, has previously demonstrated that exist at the surface of the adult cortex, and, moreover, that ischemia enhances the generation of new from these neural progenitor cells. These cells were accordingly named "Layer 1 Inhibitory Neuron Progenitor cells" (L1-INP). However, until now it was not known whether L1-INP-related neurogenesis could be induced in the normal adult cortex.

Tsuyoshi Miyakawa, Koji Ohira, and their colleagues employed fluoxetine, a , and one of the most widely used antidepressants, to stimulate the production of new neurons from L1-INP cells. A large percentage of these newly generated neurons were inhibitory GABAergic interneurons, and their generation coincided with a reduction in apoptotic cell death following ischemia. This finding highlights the potential neuroprotective response induced by this antidepressant drug. It also lends further support to the postulation that induction of adult neurogenesis in cortex is a relevant prevention/treatment option for and psychiatric disorders.

Explore further: Scientists develop non-invasive method to track nerve-cell development in live human brain

Related Stories

Stem cells are good for the brain

July 15, 2008

For some years, scientists have been speculating over why stem cells exist in the brain, as brain regeneration is limited. A German team of neuroscientists believe these stem cells help keep the brain healthy and active.

Researchers learn more about interactions in the cortex

February 24, 2011

To an untrained observer, the electrical storm that takes place over the brain’s neural network seems a chaotic flurry of activity. But as neuroscientists understand it, the millions of neurons are actually engaged in ...

Disinhibition plus instruction improve brain plasticity

April 12, 2011

(PhysOrg.com) -- The healthy brain has balance of excitatory and inhibitory signals that stimulate activity but also keep it under control. Some brain diseases, like autism and Down's syndrome, have too much inhibition, which ...

Recommended for you

Next steps in understanding brain function

August 26, 2016

The most complex piece of matter in the known universe is the brain. Neuroscientists have recently taken on the challenge to understand brain function from its intricate anatomy and structure. There is no sure way to go about ...

Scientists map brain's action center

August 25, 2016

When you reach for that pan of brownies, a ball-shaped brain structure called the striatum is critical for controlling your movement toward the reward. A healthy striatum also helps you stop yourself when you've had enough.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.