Kidney disease accounts for most of the increased risk of dying early among diabetics

One in every 10 Americans has diabetes, and a third or more of those with the condition will develop kidney disease. It may be possible to live a long and healthy life with diabetes, but once kidney disease develops, the risk of dying prematurely increases significantly, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings have significant clinical implications for the prevention and treatment of kidney disease in people with diabetes.

Because people with diabetes have an increased likelihood of dying prematurely as well as an increased likelihood of developing kidney disease, Maryam Afkarian, MD, PhD (University of Washington) and her colleagues looked to see how the former affects the latter. In other words, how much does kidney disease contribute to diabetics' increased risk of dying early?

The researchers examined 10-year in 15,046 US adults. Kidney disease was present in 9.4% and 42.3% of individuals without and with , respectively.

Among the major findings:

  • Among people without diabetes or kidney disease, 10-year mortality was 7.7%.
  • Among individuals with diabetes but without kidney disease, mortality was 11.5%.
  • Among individuals with both diabetes and kidney disease, mortality was 31.1%.
"People with type 2 diabetes have many other risk factors for cardiovascular disease and mortality, so we expected that kidney disease would predict a part, but not a majority, of higher mortality associated with type 2 diabetes. To our surprise, we found that even in the medically complex patients with type 2 diabetes, kidney disease is a very powerful predictor of premature death," said Dr. Afkarian.

She noted that the findings have important implications. "First, among people with type 2 diabetes, the subgroup with kidney disease carries most of the , so targeting intensive on this subgroup is likely to have the highest impact on overall mortality of people with diabetes. Secondly, preventing kidney disease may be a powerful way of reducing mortality in people with diabetes," said Dr. Afkarian.

More information: The article, entitled "Kidney Disease Identifies Increased Mortality Risk in Type 2 Diabetes," will appear online on January 24, 2013, doi: 10.1681/2012070718

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Ebola kills 31 people in DR Congo: WHO

55 minutes ago

An outbreak of the Ebola virus in the Democratic Republic of Congo has killed 31 people and the epidemic remains contained in a remote northwestern region, UN the World Health Organization (WHO) said Tuesday.

Dengue fever strikes models in Japan

3 hours ago

A worsening outbreak of dengue fever in Japan has claimed its first celebrities—two young models sent on assignment to the Tokyo park believed to be its source.

Japanese researchers develop 30-minute Ebola test

3 hours ago

Japanese researchers said Tuesday they had developed a new method to detect the presence of the Ebola virus in 30 minutes, with technology that could allow doctors to quickly diagnose infection.

Senegal monitors contacts of 1st Ebola patient

15 hours ago

Senegalese authorities on Monday were monitoring everyone who was in contact with a student infected with Ebola who crossed into the country, and who has lost three family members to the disease.

Cerebral palsy may be hereditary

21 hours ago

Cerebral palsy is a neurological developmental disorder which follows an injury to the immature brain before, during or after birth. The resulting condition affects the child's ability to move and in some ...

User comments