Microaneurysm turnover IDs macular edema development

Microaneurysm turnover IDs macular edema development
Microaneurysm turnover independently predicts the development of clinically significant macular edema in patients with non-proliferative diabetic retinopathy, according to a study published online Nov. 30 in Diabetes Care.

(HealthDay)—Microaneurysm (MA) turnover independently predicts the development of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR), according to a study published online Nov. 30 in Diabetes Care.

Maria Luisa Ribeiro, M.D., from the University of Coimbra in Portugal, and colleagues conducted a prospective observational study involving 410 patients (one eye per patient) with and NPDR and no prior laser treatment. Participants were followed for two years or until development of CSME. MA turnover was assessed using automated analysis of fundus photographs (RetmarkerDR). Ophthalmologic examinations were performed at baseline, six months, and at the last study visit (24 months or before ).

The researchers found that, of the 348 eyes/patients who were followed until the last visit, 26 developed CSME. CSME development was independently predicted by hemoglobin A1c levels at baseline and MA turnover (the sum of the MA formation and disappearance rates) computed during the first six months of follow-up. In the 26 eyes/patients who developed CSME, MA turnover was 11.2 ± 11.2, compared with 5.0 ± 5.2 in the remaining 322 patients (P < 0.001). There was a correlation between higher MA turnover values and earlier development of CSME. For CSME development, the positive predictive value of MA turnover was 20 percent and the negative predictive value was 96 percent.

"MA turnover calculated with the RetmarkerDR predicts development of CSME in eyes with NPDR," the authors write. "Low MA turnover values identify well the eyes that are less likely to develop CSME in a two-year period."

The authors disclosed financial ties to the Association for Innovation and Biomedical Research on Light and Image. One author disclosed to the pharmaceutical industry.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Long-term ranibizumab beneficial for macular edema

Oct 11, 2012

(HealthDay)—Long-term aggressive treatment of patients with macular edema with ranibizumab during a third year correlates with reduced mean foveal thickness (FTH) and improved best-corrected visual acuity ...

Typhoon Ma-on's eye seen in NASA satellite Images

Jul 15, 2011

The eye of a tropical cyclone is an indication of a strong storm, and Typhoon Ma-on's eye was apparent in visible and infrared imagery captured by NASA's Aqua satellite. Ma-on just achieved Category Four status ...

Recommended for you

Economic burden of prediabetes up 74 percent over five years

Nov 20, 2014

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

Gynoid fat resists metabolic risks of obesity

Nov 19, 2014

(HealthDay)—The differences in the developmental profiles of upper-body and lower-body fat depots may explain their opposing associations with obesity-related metabolic disease, according to research published ...

Treating diabetes one meal at a time

Nov 19, 2014

Recent estimates project that as many as one in three American adults will have diabetes in 2050. The American Diabetes Association observes November as American Diabetes Month, and this year's theme is America ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.