Researchers find peptide produced by giant panda fights fungi and bacteria
(Medical Xpress)—Researchers working at the Life Sciences College of Nanjing Agricultural University in China have found that giant pandas naturally produce a peptide that can kill fungi and bacteria. In their paper published in the journal Gene, the researchers describe how they came across the peptide as they were performing DNA analysis on the animals. They also report that they have been able to synthesize the peptide in their lab and have tested its antibacterial abilities.
The peptide, called cathelicidin-AM, is one of a group of cathelicidins – small cationic antimicrobial peptides that are found in many species including primates, mammals, birds, marsupials, etc. Their purpose is to protect the host from fungal, viral, bacterial and parasitic infections. They can operate as an immune response or by directly killing invaders.
The researchers believe that the newly found peptide might become one of the new tools used by medical science to aid in fighting bacterial infections – traditional methods have become less useful as bacteria have developed immunity to them. Cathelicidin-AM might be used to help infected patients or as a cleaning agent for surfaces or instruments in hospitals and other facilities.
After successfully synthesizing the peptide in their lab, the team tested its ability to kill Staphylococcus sciuri against Clindamycin, a commonly used antibiotic. They found that cathelicidin-AM was able to kill the bacteria in as little as one hour, whereas Clindamycin took nearly six.
In speaking with The Telegraph, project lead Dr Xiuwen Yan said that the newly synthesized peptide shows promise as an antimicrobial agent against a wide range of microorganisms and appears to be equally effective against drug-resistant microorganisms. He added that research into discovering new ways to battle invasive elements has become increasingly important as many microorganisms have developed immunity to conventional drugs. Research, such as that being done by the college that look into antimicrobial peptides encoded in genes, is important he added, because it offers the possibility of developing agents that don't allow microbes to develop immunity to them.
The work by the team in China is just one of many efforts currently underway studying the antimicrobial abilities of peptides. Another team, for example, funded by the UC School of Veterinary Medicine, studying feline cathelicidin has also met with some success. Their work has been published in a recent issue of PLUSONE.
More information: The cathelicidin-like peptide derived from panda genome is a potential antimicrobial peptide, Gene, Volume 492, Issue 2, 25 January 2012, Pages 368–374. dx.doi.org/10.1016… .2011.11.009 , www.sciencedirect.… 111911006652
A novel cathelicidin-like antimicrobial peptide was identified by mining genome of panda. This peptide (cathelicidin-AM) was synthesized. It showed potential antimicrobial activities against wide spectrum of microorganisms including Gram-negative and -positive bacteria, and fungi. It had similar antimicrobial abilities against both standard and clinically isolated drug-resistant strains. Cathelicidin-AM could rapidly exert its antibacterial activities. It just took less than 1 h to kill all Staphylococcus sciuri at the concentration of 2, 4 or 10 times of minimal inhibitory concentration (MIC) while clindamycin took 6 h. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analysis indicated that cathelicidin-AM killed bacteria by directly affecting bacterial cell wall and membrane. Phylogenetic analysis revealed that the panda cathelicidin had the nearest evolution relationship with dog cathelicidin. The current work provides a novel cathelicidin-like peptide with strong antimicrobial abilities.
via The Telegraph
© 2013 Medical Xpress
- Going to the dogs: University's newest patent for improving canine health Nov 29, 2011 | not rated yet | 0
- Researchers discover general recipe for making antimicrobial agents that kill bacteria Apr 18, 2011 | not rated yet | 0
- Study finds scorpion venom able to heal bacterial infections in mice Jul 13, 2012 | not rated yet | 0
- Frogs skin gives researchers the hop on bacteria Nov 09, 2011 | not rated yet | 0
- Researchers suggest novel prevention of recurrent ear infections Oct 30, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
May 23, 2013 Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.
Medical research May 23, 2013 | 5 / 5 (1) | 0 |
Aortic arch pulse wave velocity, a measure of arterial stiffness, is a strong independent predictor of disease of the vessels that supply blood to the brain, according to a new study published in the June issue the journal ...
Medical research May 23, 2013 | not rated yet | 0
Since the discovery of Prontosil in 1932, sulfonamide antibiotics have been used to combat a wide spectrum of bacterial infections, from acne to chlamydia and pneumonia. However, their side effects can include serious neurological ...
Medical research May 23, 2013 | 3 / 5 (1) | 0 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...
Medical research May 23, 2013 | 5 / 5 (3) | 0 |
Spanish researchers have discovered that the daily clearance of neutrophils from the body stimulates the release of hematopoietic stem cells from the bone marrow into the bloodstream, according to a report published today ...
Medical research May 23, 2013 | 5 / 5 (2) | 0
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
10 hours ago | 5 / 5 (2) | 5
(HealthDay)—Animals make great companions for senior citizens, but elderly people who always drive with a pet in the car are far more likely to crash than those who never drive with a pet, researchers have ...
2 hours ago | not rated yet | 0
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
10 hours ago | not rated yet | 1
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
10 hours ago | not rated yet | 0
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
10 hours ago | not rated yet | 0