Small peptide ameliorates autoimmune skin blistering disease in mice
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection.
In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke at the Institute of Anatomy and Cell Biology in Munich, Germany, report on a small peptide that blocked antibody recognition of desmogleins. Importantly, the peptide could prevent antibody-mediated skin blistering when applied topically to mice. At the cellular level, the peptide improved cell-cell adhesion and attenuated signaling pathways that are activated by antibody binding.
These results suggest that this peptide could serve as a treatment option for pemphigus vulgaris.
More information: Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering, Journal of Clinical Investigation, 2013. doi:10.1172/JCI60139
Journal reference: Journal of Clinical Investigation
Provided by Journal of Clinical Investigation
- Gatekeeper signal controls skin inflammation Jan 26, 2012 | not rated yet | 0
- (Antibody) orientation matters Dec 10, 2012 | not rated yet | 0
- Relief from red, itchy skin: Unraveling the secrets of vitamin D May 12, 2011 | not rated yet | 0
- Under the right conditions, peptide blocks HIV infection at multiple points along the way Jul 24, 2012 | not rated yet | 0
- Skin sentry cells promote distinct immune responses Jul 21, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Basic physics understanding. Could someone explain?
1 hour ago I'm trying to get a grip on some classic physics by watching a Stanford lecture. I've made it through the first one, and now in the second one all...
Change in flux of a transformer
2 hours ago Hello, As I understand, a simple transformer works by using the Input AC in the primary coil to generate magnetic field in the iron core, which...
Electric field between parallel plate capacitor
2 hours ago If you have an infinite non-conducting plate, the electric field just outside is equal to sigma / 2*epsilon. The electric field just outside a...
Why angle of projectile has 2 solutions?
3 hours ago I have the final answer of: sin2(theta) = 0.871 why does (theta) = 30.3 deg OR (theta) = 59.7 deg I get why this could be physically, but...
How much negative charge do I accumulate by touching the earth?
5 hours ago The Earth carries a negative electric charge of roughly 500 thousand Coulombs (according to different sources I've seen). If I touch the Earth I...
Indeterminism in Classical Physics
10 hours ago I was reading the Roger Penrose book Emperor's New Mind and he was explaining the determinism in Newtonian mechanics. He says that if we consider...
- More from Physics Forums - Classical Physics
More news stories
Kate O'Reilly's spring allergy survival kit includes the usual stuff - nasal sprays, allergy pills and a box of tissues. This season, she's added a new weapon to her line of defense: an app on her smartphone.
Immunology 3 hours ago | not rated yet | 0
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
Immunology 5 hours ago | 5 / 5 (2) | 0 |
(Medical Xpress)—Scientists at Emory Vaccine Center have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.
Immunology May 23, 2013 | 5 / 5 (1) | 0 |
Human breastmilk responds quickly to protect the child when there is an infection in mothers or babies, according to new international research led by The University of Western Australia.
Immunology May 23, 2013 | 5 / 5 (1) | 0
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
8 hours ago | 5 / 5 (3) | 0 |
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
2 hours ago | 5 / 5 (1) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
5 hours ago | 5 / 5 (1) | 0 |
(Medical Xpress)—Regulating the distribution of power in neurons is done by a system that makes the national electric grid look simple by comparison. Each neuron has several thousand mitochondria confined ...
23 hours ago | 4.9 / 5 (9) | 0 |
Talking on a hands-free device while behind the wheel can lead to a sharp increase in errors that could imperil other drivers on the road, according to new research from the University of Alberta.
2 hours ago | not rated yet | 0
(Medical Xpress)—Patients with diabetes who are depressed are much more likely to develop episodes of dangerously low blood sugars, or hypoglycemia, than are those who are not depressed, a new study has ...
9 hours ago | not rated yet | 0 |