Telmisartan reverses insulin resistance in mice

January 3, 2013
Telmisartan reverses insulin resistance in mice
Treating mice fed a high-fat diet with telmisartan reverses insulin resistance and glucose intolerance, but only when the peroxisome proliferator-activated receptor-δ gene is present, according to a study published online Dec. 13 in Diabetes.

(HealthDay)—Treating mice fed a high-fat diet with telmisartan reverses insulin resistance and glucose intolerance, but only when the peroxisome proliferator-activated receptor-δ (PPAR-δ) gene is present, according to a study published online Dec. 13 in Diabetes.

Li Li, from the Chongqing Institute of Hypertension in China, and colleagues examined the effects of telmisartan, an angiotensin receptor blocker, on insulin signaling and glucose uptake in wild-type mice and mice lacking the PPAR-δ gene in muscle.

The researchers found that, in cultured myotubes, treatment with telmisartan correlated with increased PPAR-δ expression and activated transcriptional activity of PPPAR-δ. In cultured myotubes with palmitate-induced , enhanced insulin-stimulated phosphorylation of Akt and Akt substrate of 160 kDa as well as translocation of Glu4 to the plasma membrane was seen with telmisartan treatment. Antagonizing PPAR-δ or phosphatidylinositol-3 kinase inhibited these effects. In cultured myotubes, insulin-stimulated glucose uptake which was reduced by palmitate could be restored by telmisartan. Similar results were observed in vivo in wild-type mice, but not PPAR-δ , with telmisartan reversing high-fat diet-induced insulin resistance and glucose intolerance.

"In summary, we demonstrate that telmisartan has a profound role in the improvement of in skeletal muscle, which is associated with activation of the PPAR-δ/phosphatidylinositol 3-kinase pathway," Li and colleagues conclude. "These findings implicate PPAR-δ as a potential therapeutic target in the treatment of hypertensive subjects with insulin resistance."

Explore further: Fewer mitochondria in offspring of parents with diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Fewer mitochondria in offspring of parents with diabetes

March 26, 2012

(HealthDay) -- Normal-weight, insulin-resistant individuals whose parents have type 2 diabetes have fewer mitochondria in their muscles due to lower expression of lipoprotein lipase (LPL), according to a study published in ...

Improving obesity-induced insulin sensitivity

June 1, 2012

In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance. In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into ...

Recommended for you

Unique molecular atlas of pancreas produced

September 23, 2016

Researchers at Karolinska Institutet have managed to produce the first molecular map of the genes that are active in the various cells of the human pancreas. They have also revealed differences in genetic activity between ...

Can long naps cause diabetes?

September 14, 2016

A study presented at a scientific congress Thursday reported a link between long naps and a higher risk of diabetes, though it couldn't say if daytime sleeping was a symptom or a cause.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.