AB blood type strong risk factor for venous blood clots

The non-O ABO blood type is the most important risk factor for venous thromboembolism (blood clots in veins), making up 20% of attributable risk for the condition, according to a new study in CMAJ (Canadian Medical Association Journal).

This finding has implications for genetic screening for thrombophilia, a to abnormal blood clotting.

Danish researchers looked at data on 66 001 people who had been followed for 33 years from 1977 through 2010 to determine whether ABO blood type is associated with an increased risk of venous blood clots in the general population. They found that the risk increased when ABO blood type was combined with factor V Leiden R506Q or prothrombin G20210A, associated with an increased risk of venous thromboembolisms. This finding confirms the conclusion of other studies. The researchers also found an 11-fold increased risk of venous thromboembolism for people with the prothrombin G20210A mutation in double dose, something other smaller trials did not pick up.

"We found an additive effect of ABO blood type on risk of venous thromboembolism when combined with factor V Leiden R506Q and prothrombin G20210A; ABO blood type was the most important risk factor for venous thromboembolism in the general population.," writes Dr. Børge G. Nordestgaard, Herlev Hospital, Copenhagen University Hospital with coauthors. "This suggests that ABO blood type should be included in genetic screening for thrombophilia."

The study was large, followed participants over a long period and follow up was 100% complete for participants. Although the study cohort was genetically homogenous compared with populations with , the ABO blood type, factor V Leiden R506Q and prothrombin G20210A are found in all ethnicities.

More information: www.cmaj.ca/lookup/doi/10.1503/cmaj.121636

Related Stories

Risk of blood clots in veins hereditary

May 31, 2011

Venous thromboembolism (VTE) is the third most common type of cardiovascular disease after coronary heart disease and stroke. Researchers at the Centre for Primary Health Care Research in Malmo have mapped the significance ...

Major illness increases venous thrombosis risk

Nov 03, 2012

(HealthDay)—People with major illnesses, including liver or kidney disease, rheumatoid arthritis, multiple sclerosis, heart failure, hemorrhagic stroke, or arterial thrombosis, have an increased risk of ...

Recommended for you

Africa's uneven health care becomes easy prey for Ebola

2 hours ago

The disparity in African countries' ability to fight Ebola has left the continent fighting an uneven struggle against a disease that doesn't respect borders—yet relatively simple measures could help, experts say.

Ebola case stokes concerns for Liberians in Texas

3 hours ago

The first case of Ebola diagnosed in the U.S. has been confirmed in a man who recently traveled from Liberia to Dallas, sending chills through the area's West African community whose leaders urged caution ...

Is Australia prepared for Ebola?

6 hours ago

Australia needs to be proactive about potential disease outbreaks like Ebola and establish a national centre for disease control.

Dallas hospital confirms first Ebola case in US

11 hours ago

A patient at a Dallas hospital has tested positive for Ebola, the first case of the disease to be diagnosed in the United States, federal health officials announced Tuesday.

User comments