Antibody response linked with rejection in pediatric kidney transplant recipients

Minnie Sarwal, MD, FRCP, PhD (California Pacific Medical Center) and her colleagues mapped the antibody immune response in 130 children who received kidney transplants through 12 different US transplant programs participating in a trial comparing complete steroid avoidance after transplantation and standard steroid therapy after transplantation. (Some patients received long-term steroids after transplantation as a treatment to potentially protect the new organ from antibody-mediated injury, while others received no steroids.) Patients were monitored for two years after transplantation.

"The development of antibodies were confirmed to injure the transplant, though the incidence of this antibody-mediated injury to the transplant was quite low at only about 6%," said Dr. Sarwal. Patients with these antibodies were more likely to experience organ injury and rejection than patients without these antibodies.

Also, steroids did not seem to provide a benefit. "There was no difference in the immune response in children who did not receive steroids, though there was a huge benefit in their growth, in lower blood pressures, and lower cholesterol levels, supporting the importance of avoiding steroids in children after transplantation wherever possible," she added.

The researchers recommend monitoring recipients for the presence of antibodies directed against transplanted organs at various stages and customizing immunosuppressive treatments to prevent rejection.

More information: The article, entitled "Humoral Immunity Associates with Outcomes in Pediatric Renal Transplantation," will appear online on February 28, 2013, doi: 10.1681/ASN.2012070663

Journal reference: Journal of the American Society of Nephrology

Provided by American Society of Nephrology