New research identifies effective treatment for common gynecological problem

New research from the Los Angeles Biomedical Research Institute (LA BioMed) found a progestogen-only treatment halted bleeding in women suffering from extremely heavy periods, according to the study published online by the American Journal of Obstetrics and Gynecology.

"Excessive uterine bleeding is a common problem we see in gynecological practices and emergency rooms. It can interfere with women's daily activities and put them at risk for anemia and other more serious caused by ," said Anita L. Nelson, MD, a LA BioMed lead investigator and corresponding author of the study. "Until now, there has been no -approved products for short-term treatment of this condition. Based on our study, we conclude that this new progestogen-only treatment is effective in stopping acute abnormal uterine bleeding."

Within five days of receiving the , bleeding had ceased in 44 of the 48 women in the study, and the other four were only experiencing spotting. The mean time to bleeding cessation was 2.6 days, leading the researchers to conclude the progestogen-only treatment was an effective short-term therapy for acute abnormal uterine bleeding.

In the pilot study, the patients received a 150-milligram injection of Depomedroxyprogesterone acetate (DMPA) and then were given acetate (MPA) 20 milligram pills that were to be taken orally every eight hours for three days.

"This is the largest prospective study to date to measure the effectiveness of a proposed for excessive uterine bleeding," said Dr. Nelson. "The women in the study experienced excellent success with this relatively low dose progestogen-only therapy. This therapy also has the potential for offering longer-term protection than prior therapies."

The therapy was shown to halt bleeding rapidly while appropriate testing could identify the underlying causes of the excessive bleeding. As such, Dr. Nelson said the therapy provides a "temporary bridge to long-term targeted therapies." She also said the regimen had "good compliance, few side effects and high patient satisfaction." In addition, she said it was an attractive treatment option for women with contraindications to estrogen, those who need more prolonged therapy and those who may have difficulty with daily pill administration.

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Triglycerides significantly elevated in women with GDM

Jan 29, 2015

(HealthDay)—For women with gestational diabetes mellitus (GDM), triglycerides are significantly elevated throughout pregnancy, according to a review published online Jan. 22 in BJOG: An International Jo ...

Safer childbirth for women everywhere

Jan 29, 2015

Few women in developed countries die of blood loss in childbirth, but in remote areas and developing countries, an estimated 100,000 die every year from post-partum haemorrhage. 

10 tips to prepare for pregnancy

Jan 29, 2015

For women of childbearing age looking to become pregnant, it is never too early to engage in healthy habits to ensure that she has a healthy pregnancy and her child has a healthy first step.

AAFP advocates for planned vaginal birth after cesarean

Jan 28, 2015

(HealthDay)—A planned labor and vaginal birth after cesarean (LAC/VBAC) is an appropriate option for most women with a history of prior cesarean birth, according to a clinical practice guideline published ...

Women diagnosed with PCOS twice as likely to be hospitalized

Jan 27, 2015

Women diagnosed with polycystic ovary syndrome - the most common hormone disorder in women of reproductive age - face a heightened risk of developing heart disease, diabetes, mental health conditions, reproductive disorders ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.