Gender influences ischemic time, outcomes after STEMI

February 18, 2013
Gender influences ischemic time, outcomes after STEMI
After ST-segment elevation myocardial infarction and primary percutaneous coronary intervention, women have longer ischemic times and are at a higher risk than men of early all-cause and cardiac mortality, according to research published in the Feb. 1 issue of The American Journal of Cardiology.

(HealthDay)—After ST-segment elevation myocardial infarction (STEMI) and primary percutaneous coronary intervention (PCI), women have longer ischemic times and are at a higher risk than men of early all-cause and cardiac mortality, according to research published in the Feb. 1 issue of The American Journal of Cardiology.

In an effort to examine the influence of gender on ischemic times and outcomes, Matthijs A. Velders, M.D., of the Leiden University Medical Center in the Netherlands, and colleagues used multicenter registry data for 3,483 patients (25 percent women) with STEMI treated with primary PCI at three hospitals.

The researchers found that ischemic times were significantly longer for women than men (192 versus 175 minutes), but this was due to age and comorbidity. At seven days and at one year, all-cause mortality was significantly higher for women than for men (6 versus 3 percent at seven days; 9.9 versus 6.6 percent at one year). After adjustment, female gender predicted all-cause and at seven days (hazard ratio, 1.61 and 1.58, respectively), but not at one year. For cardiogenic shock, gender was an independent effect modifier leading to considerably worse outcomes for women.

"In conclusion, ischemic times remain longer in women because of age and comorbidity. Female gender independently predicted early all-cause and cardiac mortality after primary , and a strong interaction between gender and cardiogenic shock was observed," the authors write.

Explore further: Time trends in STEMI -- improved treatment and outcome but gender gap persists

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Statewide coordinated STEMI approach deemed successful

June 5, 2012

(HealthDay) -- A statewide coordinated effort across hospitals and emergency medical service (EMS) providers to transport patients with ST-segment elevation myocardial infarction (STEMI) to hospitals providing percutaneous ...

Multiple factors motivate no reperfusion in STEMI

August 2, 2012

(HealthDay) -- For patients presenting with ST-segment elevation myocardial infarction (STEMI), the decision for no reperfusion is usually multifactorial, with the most common factor being advanced age, according to a study ...

Women more likely to die from myocardial infarction than men

October 20, 2012

Women are more likely to die from a myocardial infarction than men, according to research presented at the Acute Cardiac Care Congress 2012. The gender gap in mortality was independent of patient characteristics, revascularisation ...

Raised risk of ischemic stroke in women with A-fib explored

December 10, 2012

(HealthDay)—Women with atrial fibrillation (AF) have a higher risk of ischemic stroke than men with AF, related in part to differences in the percent time in the therapeutic range (TTR) associated with warfarin anticoagulation ...

Recommended for you

Rate of decline of cardiovascular deaths slows in US

June 29, 2016

In a study published online by JAMA Cardiology, Stephen Sidney, M.D., M.P.H., of Kaiser Permanente Northern California, Oakland, and colleagues examined recent national trends in death rates due to all cardiovascular disease ...

Keeping the heart's electrical system running

June 28, 2016

A drug commonly used to treat high blood pressure has been shown to significantly reduce the risk of blocked electrical impulses to the heart and could be an effective treatment for certain types of heart disease known as ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.