Grape seed and skin extract—a weapon in the fight against kidney disease caused by high-fat diets

New insight into grape seed extract as a therapeutic and preventative measure to fight obesity-induced kidney damage is presented in a new study. Grape seed and skin extract (GSSE) is known to contain powerful antioxidants. This study, published in the journal Applied Physiology, Nutrition, and Metabolism, is the first to make a link between GSSEs and high-fat-diet-induced renal disease.

The authors examined the effect of GSSE processed from a grape cultivar ('Carignan') of Vitis vinifera from northern Tunisia on rats. Rats were fed a high-fat diet that induced a low-grade reno-lipotoxicity, that is, associated with lipids. This was characterized by elevations in plasma urea and protein in the urine. The researchers found increased deposits of triglycerides (TG) (especially ), increased signs of oxidative stress and depleted copper levels in the kidneys. There was also histological evidence of disturbance in the kidney structure. When the animals received GSSE at 500 mg/kg bw (which corresponds to 35g/day for a 70 kg human adult) along with the high-fat diet there was a partial reversal of the TG deposition as well as the histological damage. The authors suggest polyphenols including resveratrol are likely the components in GSSE responsible for the positive effects. Furthermore the GSSE prevented the oxidative stress and copper depletion.

"In our research, obesity-induced leaky kidney and proteinuria are shown to be prevented by GSSE, which suggests the use of GSSE as a preventive nutriceutical for high-," said co-author Kamel Charradi, a researcher with the Laboratory of Bioactive Substance at the Center of Biotechnology of Borj-Cedria (CBBC) in Tunisia. This research group has previously published work showing the benefits of GSSE in combating obesity, heart dysfunction, brain lipotoxicity and .

More information: The article "Grape seed and skin extract alleviates high-fat-diet-induced renal lipotoxicity and prevents copper depletion in rats" is available Open Access in the journal Applied Physiology, Nutrition, and Metabolism, DOI: 10.1139/apnm-2012-0416

add to favorites email to friend print save as pdf

Related Stories

Do low-carb diets damage the kidneys?

May 31, 2012

Low-carbohydrate, high-protein diets—like the Atkins diet—have been popular among dieters for years. For just as long, experts have worried that such diets might be harmful to the kidneys. A study appearing in an ...

Simple blood test predicts obesity

Oct 31, 2008

According to new research from the Monell Center, the degree of change in blood triglyceride levels following a fatty meal may indicate susceptibility to diet-induced obesity. The findings open doors to new methods of identifying ...

Recommended for you

AMA launches three programs for physician wellness

1 hour ago

(HealthDay)—Physicians' personal health is a global concern and three initiatives are being developed to encourage positive change, according to a report from the American Medical Association (AMA).

User comments